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Erc1 ELKS/RAB6-interacting/CAST family member 1 [ Mus musculus (house mouse) ]

Gene ID: 111173, updated on 8-May-2016
Official Symbol
Erc1provided by MGI
Official Full Name
ELKS/RAB6-interacting/CAST family member 1provided by MGI
Primary source
MGI:MGI:2151013
See related
Ensembl:ENSMUSG00000030172 Vega:OTTMUSG00000044533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ELKS; CAST2; Elks1; Rab6ip2; RAB6IP2A; RAB6IP2B; mKIAA1081; 4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik
Orthologs
Location:
6; 6 F1
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (119570796..119849739, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119520814..119798168, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 5B Neighboring gene predicted gene, 40396 Neighboring gene predicted gene, 30690 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene RAD52 homolog, DNA repair protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4) 
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
Rab GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ELKS/Rab6-interacting/CAST family member 1
Names
CAZ-associated structural protein 2
RAB6-interacting protein 2
Rab6 interacting protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053204.2NP_444434.2  ELKS/Rab6-interacting/CAST family member 1 isoform 1

    See identical proteins and their annotated locations for NP_444434.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125102, AC128662, AC161060
    Consensus CDS
    CCDS39611.1
    UniProtKB/TrEMBL
    F8VPM7
    Related
    ENSMUSP00000139031, OTTMUSP00000065550, ENSMUST00000183703, OTTMUST00000117204
    Conserved Domains (3) summary
    pfam09457
    Location:10721112
    RBD-FIP; FIP domain
    pfam10174
    Location:154986
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like
  2. NM_178085.3NP_835186.1  ELKS/Rab6-interacting/CAST family member 1 isoform 2

    See identical proteins and their annotated locations for NP_835186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125102, AK048990
    Consensus CDS
    CCDS20476.1
    UniProtKB/Swiss-Prot
    Q99MI1
    Related
    ENSMUSP00000078534, OTTMUSP00000065558, ENSMUST00000079582, OTTMUST00000117213
    Conserved Domains (1) summary
    pfam10174
    Location:3345
    Cast; RIM-binding protein of the cytomatrix active zone

RNA

  1. NR_104484.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125102, AC128662, AC161060

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    119570796..119849739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505378.2XP_006505441.1  

    Conserved Domains (3) summary
    pfam09457
    Location:848888
    RBD-FIP; FIP domain
    pfam10174
    Location:1762
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:177243
    Bap31; B-cell receptor-associated protein 31-like
  2. XM_006505373.2XP_006505436.1  

    See identical proteins and their annotated locations for XP_006505436.1

    Related
    ENSMUSP00000139152, OTTMUSP00000065552, ENSMUST00000185139, OTTMUST00000117206
    Conserved Domains (2) summary
    pfam09457
    Location:10441084
    RBD-FIP; FIP domain
    pfam10174
    Location:154958
    Cast; RIM-binding protein of the cytomatrix active zone
  3. XM_006505370.2XP_006505433.1  

    See identical proteins and their annotated locations for XP_006505433.1

    UniProtKB/TrEMBL
    F8VPM7
    Conserved Domains (3) summary
    pfam09457
    Location:10721112
    RBD-FIP; FIP domain
    pfam10174
    Location:154986
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like
  4. XM_011241149.1XP_011239451.1  

    Conserved Domains (2) summary
    pfam09457
    Location:9961036
    RBD-FIP; FIP domain
    pfam10174
    Location:154910
    Cast; RIM-binding protein of the cytomatrix active zone
  5. XM_011241146.1XP_011239448.1  

    See identical proteins and their annotated locations for XP_011239448.1

    UniProtKB/TrEMBL
    V9GXF0
    Related
    ENSMUSP00000139118, OTTMUSP00000065556, ENSMUST00000183911, OTTMUST00000117210
    Conserved Domains (3) summary
    pfam05087
    Location:738854
    Rota_VP2; Rotavirus VP2 protein
    pfam09457
    Location:10401080
    RBD-FIP; FIP domain
    pfam10174
    Location:154954
    Cast; RIM-binding protein of the cytomatrix active zone
  6. XM_011241148.1XP_011239450.1  

    Related
    ENSMUSP00000138823, OTTMUSP00000065554, ENSMUST00000183880, OTTMUST00000117208
    Conserved Domains (2) summary
    pfam09457
    Location:10001040
    RBD-FIP; FIP domain
    pfam10174
    Location:154914
    Cast; RIM-binding protein of the cytomatrix active zone
  7. XM_011241145.1XP_011239447.1  

    See identical proteins and their annotated locations for XP_011239447.1

    Conserved Domains (2) summary
    pfam09457
    Location:10441084
    RBD-FIP; FIP domain
    pfam10174
    Location:154958
    Cast; RIM-binding protein of the cytomatrix active zone
  8. XM_011241144.1XP_011239446.1  

    See identical proteins and their annotated locations for XP_011239446.1

    UniProtKB/TrEMBL
    V9GXP8
    Related
    ENSMUSP00000139256, OTTMUSP00000065553, ENSMUST00000184864, OTTMUST00000117207
    Conserved Domains (4) summary
    pfam05087
    Location:766882
    Rota_VP2; Rotavirus VP2 protein
    pfam09457
    Location:10681108
    RBD-FIP; FIP domain
    pfam10174
    Location:154982
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like
  9. XM_011241147.1XP_011239449.1  

    Related
    ENSMUSP00000139030, OTTMUSP00000065551, ENSMUST00000184838, OTTMUST00000117205
    Conserved Domains (3) summary
    pfam09457
    Location:10281068
    RBD-FIP; FIP domain
    pfam10174
    Location:154942
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like
  10. XM_006505371.2XP_006505434.1  

    See identical proteins and their annotated locations for XP_006505434.1

    UniProtKB/TrEMBL
    F8VPM7
    Conserved Domains (3) summary
    pfam09457
    Location:10721112
    RBD-FIP; FIP domain
    pfam10174
    Location:154986
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like
  11. XM_011241143.1XP_011239445.1  

    See identical proteins and their annotated locations for XP_011239445.1

    UniProtKB/TrEMBL
    F8VPM7
    Related
    ENSMUSP00000032279, ENSMUST00000032279
    Conserved Domains (3) summary
    pfam09457
    Location:10721112
    RBD-FIP; FIP domain
    pfam10174
    Location:154986
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like
  12. XM_011241142.1XP_011239444.1  

    See identical proteins and their annotated locations for XP_011239444.1

    UniProtKB/TrEMBL
    F8VPM7
    Conserved Domains (3) summary
    pfam09457
    Location:10721112
    RBD-FIP; FIP domain
    pfam10174
    Location:154986
    Cast; RIM-binding protein of the cytomatrix active zone
    cl02219
    Location:401467
    Bap31; B-cell receptor-associated protein 31-like

RNA

  1. XR_868848.1 RNA Sequence

  2. XR_868847.1 RNA Sequence

  3. XR_868846.1 RNA Sequence

  4. XR_868845.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    121405104..121685429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)