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DNMT1 DNA methyltransferase 1 [ Delphinapterus leucas (beluga whale) ]

Gene ID: 111166000, updated on 11-Apr-2024

Summary

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Gene symbol
DNMT1
Gene description
DNA methyltransferase 1
See related
Ensembl:ENSDLEG00000008585
Gene type
protein coding
RefSeq status
MODEL
Organism
Delphinapterus leucas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
41
Annotation release Status Assembly Chr Location
101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098054.1 (1151193..1193861)
100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160955.1 (1129696..1172367)

NW_022098054.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene thimet oligopeptidase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA (cytosine-5-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA (cytosine-5)-methyltransferase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228892v3 Primary Assembly

Genomic

  1. NW_022098054.1 Reference ASM228892v3 Primary Assembly

    Range
    1151193..1193861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030764450.1 → XP_030620310.1  DNA (cytosine-5)-methyltransferase 1 isoform X6

    UniProtKB/TrEMBL
    A0A7F8KHA5
    Conserved Domains (6) summary
    COG0270
    Location:1178 → 1635
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd04711
    Location:1005 → 1141
    BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    cd04760
    Location:794 → 917
    BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    pfam02008
    Location:685 → 731
    zf-CXXC; CXXC zinc finger domain
    pfam06464
    Location:50 → 139
    DMAP_binding; DMAP1-binding Domain
    pfam12047
    Location:444 → 573
    DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

  2. XM_022557182.2 → XP_022412890.1  DNA (cytosine-5)-methyltransferase 1 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9LU41
    Conserved Domains (6) summary
    COG0270
    Location:1178 → 1293
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd04711
    Location:1005 → 1141
    BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    cd04760
    Location:794 → 917
    BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    pfam02008
    Location:685 → 731
    zf-CXXC; CXXC zinc finger domain
    pfam06464
    Location:50 → 139
    DMAP_binding; DMAP1-binding Domain
    pfam12047
    Location:444 → 573
    DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

  3. XM_022557179.2 → XP_022412887.1  DNA (cytosine-5)-methyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9M0U3
    Related
    ENSDLEP00000011773.1, ENSDLET00000012988.1
    Conserved Domains (7) summary
    COG0270
    Location:1178 → 1635
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd04711
    Location:1005 → 1141
    BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    cd04760
    Location:794 → 917
    BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    pfam02008
    Location:685 → 731
    zf-CXXC; CXXC zinc finger domain
    pfam06464
    Location:50 → 139
    DMAP_binding; DMAP1-binding Domain
    pfam10243
    Location:206 → 407
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12047
    Location:444 → 573
    DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

  4. XM_022557180.2 → XP_022412888.1  DNA (cytosine-5)-methyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9M696
    Conserved Domains (7) summary
    COG0270
    Location:1177 → 1634
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd04711
    Location:1004 → 1140
    BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    cd04760
    Location:793 → 916
    BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    pfam02008
    Location:684 → 730
    zf-CXXC; CXXC zinc finger domain
    pfam06464
    Location:50 → 139
    DMAP_binding; DMAP1-binding Domain
    pfam10243
    Location:205 → 406
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12047
    Location:443 → 572
    DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

  5. XM_022557183.2 → XP_022412891.1  DNA (cytosine-5)-methyltransferase 1 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9LVX4
    Conserved Domains (6) summary
    COG0270
    Location:1009 → 1466
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd04711
    Location:836 → 972
    BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    cd04760
    Location:625 → 748
    BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    pfam02008
    Location:516 → 562
    zf-CXXC; CXXC zinc finger domain
    pfam10243
    Location:37 → 177
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12047
    Location:275 → 404
    DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

  6. XM_022557181.2 → XP_022412889.1  DNA (cytosine-5)-methyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9LT81
    Conserved Domains (7) summary
    COG0270
    Location:1137 → 1594
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd04711
    Location:964 → 1100
    BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    cd04760
    Location:753 → 876
    BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
    pfam02008
    Location:644 → 690
    zf-CXXC; CXXC zinc finger domain
    pfam06464
    Location:17 → 98
    DMAP_binding; DMAP1-binding Domain
    pfam10243
    Location:165 → 366
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12047
    Location:403 → 532
    DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
Nucleotide Protein
Heading Accession and Version

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