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    CIT citron (rho-interacting, serine/threonine kinase 21) [ Homo sapiens ]

    Gene ID: 11113, updated on 20-May-2012
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    Summary

    Official Symbol
    CITprovided by HGNC
    Official Full Name
    citron (rho-interacting, serine/threonine kinase 21)provided by HGNC
    Primary source
    HGNC:1985
    See related
    Ensembl:ENSG00000122966; HPRD:09289; MIM:605629; Vega:OTTHUMG00000134325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRIK; STK21; KIAA0949
    Summary
    This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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    Genomic context

    Location :
    12q24
    Sequence :
    Chromosome: 12; NC_000012.11 (120123595..120315095, complement)
    See CIT in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 233 Neighboring gene protein kinase, AMP-activated, beta 1 non-catalytic subunit Neighboring gene microRNA 1178 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene coiled-coil domain containing 64

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. p27(Kip1) controls cytokinesis via the regulation of citron kinase activation. Serres MP, et al. J Clin Invest, 2012 Mar 1. PMID 22293177.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Citron kinase controls abscission through RhoA and anillin. Gai M, et al. Mol Biol Cell, 2011 Oct. PMID 21849473.
    4. Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain. Ding J, et al. Protein Cell, 2011 Jun. PMID 21748597.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. p27 has a role in cytokinesis via the regulation of citron-K activity
      Title: p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
    2. CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA and anillin.
      Title: Citron kinase controls abscission through RhoA and anillin.
    3. Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
      Title: Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain.
    4. CITRON has a role in proliferation of hepatocellular carcinoma cells
      Title: RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells.
    5. Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
      Title: Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
    9. Single nucleotide polymorphisms associated with bipolar disorder.
      Title: Evidence of association between bipolar disorder and Citron on chromosome 12q24.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O14578 Q9NRI5 DISC1    HPRD  PubMed  
    O14578 P78352 DLG4    HPRD  PubMed  
    O14578 Q05586 GRIN1    HPRD  PubMed  
    O14578 O15399 GRIN2D    HPRD  PubMed  
    O14578 P61586 RHOA    HPRD  PubMed  
    O14578 P08134 RHOC    HPRD  PubMed  
    BioGRID:116290 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:116290 BioGRID:111817 RAC1    BioGRID  PubMed Far Western 
    BioGRID:116290 BioGRID:106880 RHOA    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:116290 BioGRID:106881 RHOB    BioGRID  PubMed Far Western; Two-hybrid 
    BioGRID:116290 BioGRID:106882 RHOC    BioGRID  PubMed Two-hybrid 
    BioGRID:116290 BioGRID:106883 RND3    BioGRID  PubMed Two-hybrid 
    BioGRID:116290 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116290 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    small GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    generation of neurons ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    citron Rho-interacting kinase
    Names
    citron Rho-interacting kinase
    serine/threonine-protein kinase 21
    NP_001193928.1
    NP_009105.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029792.1 RefSeqGene

      Range
      5001..196501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206999.1 → NP_001193928.1  citron Rho-interacting kinase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY257469, AY681966
      Consensus CDS
      CCDS55891.1
      UniProtKB/Swiss-Prot
      O14578
      Related
      ENSP00000376306, OTTHUMP00000239872, ENST00000392521, OTTHUMT00000401847
      Conserved Domains (8) summary
      cd00029
      Location:1405 – 1453
      Blast Score: 143
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      COG1196
      Location:971 – 1338
      Blast Score: 139
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      TIGR02168
      Location:469 – 882
      Blast Score: 214
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd05601
      Location:95 – 422
      Blast Score: 1682
      STKc_CRIK; Catalytic domain of the Protein Serine/Threonine Kinase, Citron Rho-interacting kinase
      PHA03307
      Location:1948 – 2036
      Blast Score: 102
      PHA03307; transcriptional regulator ICP4; Provisional
      smart00220
      Location:97 – 360
      Blast Score: 633
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl00273
      Location:1488 – 1600
      Blast Score: 119
      PH-like; Pleckstrin homology-like domain
      cl02434
      Location:1635 – 1931
      Blast Score: 634
      CNH; CNH domain

    2. NM_007174.2 → NP_009105.1  citron Rho-interacting kinase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AY257469, AY681966
      Consensus CDS
      CCDS9192.1
      UniProtKB/Swiss-Prot
      O14578
      Related
      ENSP00000261833, OTTHUMP00000166060, ENST00000261833, OTTHUMT00000259410
      Conserved Domains (8) summary
      cd00029
      Location:1363 – 1411
      Blast Score: 142
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      COG1196
      Location:929 – 1296
      Blast Score: 143
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      TIGR02168
      Location:426 – 840
      Blast Score: 164
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd05601
      Location:95 – 422
      Blast Score: 1681
      STKc_CRIK; Catalytic domain of the Protein Serine/Threonine Kinase, Citron Rho-interacting kinase
      PHA03307
      Location:1906 – 1994
      Blast Score: 102
      PHA03307; transcriptional regulator ICP4; Provisional
      smart00220
      Location:97 – 360
      Blast Score: 634
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl00273
      Location:1446 – 1558
      Blast Score: 120
      PH-like; Pleckstrin homology-like domain
      cl02434
      Location:1593 – 1889
      Blast Score: 634
      CNH; CNH domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      120123595..120315095, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      117131727..117325161, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC002563.1 AAB71327.1
    genomic AC004813.2 (10825..52445) None
    genomic AC079317.25 (74603..147861) None
    genomic CH471054.1 EAW98155.1
      EAW98156.1
      EAW98157.1
      EAW98158.1
    mRNA AB023166.2 BAA76793.2
    mRNA AK123136.1 None
    mRNA AY209000.1 AAP43922.1
    mRNA AY257469.1 AAP13528.1
    mRNA AY681966.1 AAV87216.1
    mRNA BC008127.1 None
    mRNA BC047647.1 None
    other-genetic BC156529.1 AAI56530.1
    other-genetic BC172522.1 AAI72522.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14578.2 GenPept UniProtKB/Swiss-Prot:O14578
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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