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ATE1 arginyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 11101, updated on 8-May-2016
Official Symbol
ATE1provided by HGNC
Official Full Name
arginyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:782
See related
Ensembl:ENSG00000107669 HPRD:06979; MIM:607103; Vega:OTTHUMG00000019178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Orthologs
Location:
10q26.13
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (121740421..121928801, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123499939..123688149, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 2 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene ATE1 antisense RNA 1 Neighboring gene uncharacterized LOC102724746 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene transforming acidic coiled-coil containing protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arginyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein arginylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein arginylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
arginyl-tRNA--protein transferase 1
Names
R-transferase 1
arginine-tRNA--protein transferase 1
arginyl-tRNA-protein transferase
NP_001001976.1
NP_001275663.1
NP_001275664.1
NP_001275665.1
NP_008972.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001976.2NP_001001976.1  arginyl-tRNA--protein transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001001976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC025947, AF079098, AK124669, AL731566, HY046979
    Consensus CDS
    CCDS31300.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3
    Related
    ENSP00000224652, ENST00000224652
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:290433
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  2. NM_001288734.1NP_001275663.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001275663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC025947, AF079098, AK124669, AK296356, AK303604, HY046979
    Consensus CDS
    CCDS73211.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, B4DK25, B4E107
    Related
    ENSP00000444852, ENST00000543447
    Conserved Domains (1) summary
    pfam04377
    Location:175318
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  3. NM_001288735.1NP_001275664.1  arginyl-tRNA--protein transferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001275664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AF079099, AK124669, AK303604, AL731566, HY046979
    Consensus CDS
    CCDS73212.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, B4E107
    Related
    ENSP00000358036, ENST00000369040
    Conserved Domains (1) summary
    pfam04377
    Location:198337
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  4. NM_001288736.1NP_001275665.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus and a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AC025947, AF079098, AF079099, AK124669, AL731566
    Consensus CDS
    CCDS73213.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3, F5GXE4
    Related
    ENSP00000440881, ENST00000540606
    Conserved Domains (2) summary
    pfam04376
    Location:985
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:287426
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  5. NM_007041.3NP_008972.2  arginyl-tRNA--protein transferase 1 isoform 2

    See identical proteins and their annotated locations for NP_008972.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a unique internal segment.
    Source sequence(s)
    AC025947, AF079098, AF079099, AK124669, AL731566, HY046979
    Consensus CDS
    CCDS31299.1
    UniProtKB/Swiss-Prot
    O95260
    UniProtKB/TrEMBL
    B3KWA3
    Related
    ENSP00000358039, OTTHUMP00000020637, ENST00000369043, OTTHUMT00000050738
    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:294433
    ATE_C; Arginine-tRNA-protein transferase, C terminus

RNA

  1. NR_110006.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5'-terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC025947, AF079098, AK124669, AL731566

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    121740421..121928801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269459.2XP_005269516.1  

    Conserved Domains (2) summary
    pfam04376
    Location:985
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:330469
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  2. XM_005269458.1XP_005269515.1  

    Conserved Domains (2) summary
    pfam04376
    Location:2192
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:337476
    ATE_C; Arginine-tRNA-protein transferase, C terminus
  3. XM_011539183.1XP_011537485.1  

    Conserved Domains (2) summary
    pfam04376
    Location:126
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:203324
    ATE_C; Arginine-tRNA-protein transferase, C terminus

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    123784690..123973053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)