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PTPN21 protein tyrosine phosphatase, non-receptor type 21 [ Homo sapiens (human) ]

Gene ID: 11099, updated on 12-May-2016
Official Symbol
PTPN21provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 21provided by HGNC
Primary source
HGNC:HGNC:9651
See related
Ensembl:ENSG00000070778 HPRD:04468; MIM:603271; Vega:OTTHUMG00000170766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPD1; PTPRL10
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
Orthologs
Location:
14q31.3
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (88465778..88554779, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88932122..89021123, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370613 Neighboring gene uncharacterized LOC105370612 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene spermatogenesis associated 7 Neighboring gene uncharacterized LOC105370614 Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene echinoderm microtubule associated protein like 5 Neighboring gene tetratricopeptide repeat domain 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type 21
Names
dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
protein-tyrosine phosphatase D1
NP_008970.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046949.1 RefSeqGene

    Range
    5001..94002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007039.3NP_008970.2  tyrosine-protein phosphatase non-receptor type 21

    See identical proteins and their annotated locations for NP_008970.2

    Status: REVIEWED

    Source sequence(s)
    AL049834, AL162171, BM930068, DA860560, X79510
    Consensus CDS
    CCDS9884.1
    UniProtKB/Swiss-Prot
    Q16825
    Related
    ENSP00000452414, OTTHUMP00000244372, ENST00000556564, OTTHUMT00000410303
    Conserved Domains (6) summary
    smart00194
    Location:8961166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24222
    B41; Band 4.1 homologues
    cd00047
    Location:9231166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam09379
    Location:27105
    FERM_N; FERM N-terminal domain
    cd13188
    Location:217307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14473
    Location:116214
    FERM_B-lobe; FERM domain B-lobe

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    88465778..88554779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720011.2XP_006720074.1  

    See identical proteins and their annotated locations for XP_006720074.1

    Conserved Domains (4) summary
    smart00194
    Location:7731043
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8001043
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:94184
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14473
    Location:2791
    FERM_B-lobe; FERM domain B-lobe
  2. XM_011536367.1XP_011534669.1  

    See identical proteins and their annotated locations for XP_011534669.1

    UniProtKB/Swiss-Prot
    Q16825
    Conserved Domains (6) summary
    smart00194
    Location:8961166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24222
    B41; Band 4.1 homologues
    cd00047
    Location:9231166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam09379
    Location:27105
    FERM_N; FERM N-terminal domain
    cd13188
    Location:217307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14473
    Location:116214
    FERM_B-lobe; FERM domain B-lobe
  3. XM_005267287.1XP_005267344.1  

    See identical proteins and their annotated locations for XP_005267344.1

    UniProtKB/Swiss-Prot
    Q16825
    Conserved Domains (6) summary
    smart00194
    Location:8961166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24222
    B41; Band 4.1 homologues
    cd00047
    Location:9231166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam09379
    Location:27105
    FERM_N; FERM N-terminal domain
    cd13188
    Location:217307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14473
    Location:116214
    FERM_B-lobe; FERM domain B-lobe
  4. XM_011536369.1XP_011534671.1  

    Conserved Domains (3) summary
    smart00194
    Location:692962
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:719962
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:13103
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
  5. XM_011536368.1XP_011534670.1  

    See identical proteins and their annotated locations for XP_011534670.1

    Conserved Domains (4) summary
    smart00194
    Location:7731043
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8001043
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:94184
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14473
    Location:2791
    FERM_B-lobe; FERM domain B-lobe

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    88869992..88958966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)