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PRSS23 protease, serine 23 [ Homo sapiens (human) ]

Gene ID: 11098, updated on 26-May-2016
Official Symbol
PRSS23provided by HGNC
Official Full Name
protease, serine 23provided by HGNC
Primary source
HGNC:HGNC:14370
See related
Ensembl:ENSG00000150687 HPRD:07149; Vega:OTTHUMG00000167226
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIG13; SPUVE; ZSIG13
Summary
This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Orthologs
Location:
11q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (86791059..86952910)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (86511288..86522275)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene malic enzyme 3 Neighboring gene uncharacterized LOC105379410 Neighboring gene uncharacterized LOC102724775 Neighboring gene MOB family member 4, phocein pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 13 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 2 pseudogene Neighboring gene uncharacterized LOC100506368 Neighboring gene frizzled class receptor 4 Neighboring gene uncharacterized LOC105369422 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC5107, DKFZp451O043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
serine protease 23
Names
protease, serine, 23
putative secreted protein Zsig13
serine protease, umbilical endothelium

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293178.1NP_001280107.1  serine protease 23 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK304301, AP000654, CX871294
    UniProtKB/Swiss-Prot
    O95084
    Conserved Domains (1) summary
    cl21584
    Location:196304
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001293179.1NP_001280108.1  serine protease 23 isoform c precursor

    See identical proteins and their annotated locations for NP_001280108.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AP000654, BP206707, CX871294
    Consensus CDS
    CCDS8278.1
    UniProtKB/Swiss-Prot
    O95084
    Related
    ENSP00000280258, OTTHUMP00000235513, ENST00000280258, OTTHUMT00000393805
    Conserved Domains (1) summary
    cl21584
    Location:147255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_001293180.1NP_001280109.1  serine protease 23 isoform c precursor

    See identical proteins and their annotated locations for NP_001280109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AP000654, DA895063, DN917578
    Consensus CDS
    CCDS8278.1
    UniProtKB/Swiss-Prot
    O95084
    Conserved Domains (1) summary
    cl21584
    Location:147255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_007173.5NP_009104.2  serine protease 23 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AP000654, CX871294, DA910788
    Conserved Domains (1) summary
    cl21584
    Location:228336
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_120591.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon and contains four alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000654, BC063022, BU634437, CX871294
    Related
    ENST00000532234, OTTHUMT00000393806
  2. NR_120592.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000654, AU279649, BC063022, BU634437, CX871294
    Related
    ENST00000533902, OTTHUMT00000393807
  3. NR_120593.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000654, AP001528, CX871294, DA600625

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    86791059..86952910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    86387855..86550040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)