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    WDR5 WD repeat domain 5 [ Homo sapiens ]

    Gene ID: 11091, updated on 11-May-2012

    Summary

    Official Symbol
    WDR5provided by HGNC
    Official Full Name
    WD repeat domain 5provided by HGNC
    Primary source
    HGNC:12757
    See related
    Ensembl:ENSG00000196363; HPRD:10614; MIM:609012; Vega:OTTHUMG00000131707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWD3; BIG-3
    Summary
    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    9q34
    Sequence :
    Chromosome: 9; NC_000009.11 (137001210..137025094)
    See WDR5 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130548 Neighboring gene bromodomain containing 3 Neighboring gene ADP-ribosylation factor 4 pseudogene 1 Neighboring gene RNA, U6atac small nuclear (U12-dependent splicing) Neighboring gene retinoid X receptor, alpha Neighboring gene microRNA 4669

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_060058.1 NP_005924.2 MLL    BIND  PubMed WDR5 interacts with MLL. This interaction was modeled on a demonstrated interaction between WDR5 from an unspecified species and human MLL. 
    P61964 P54259 ATN1    HPRD  PubMed  
    P61964 Q9NS73 MBIP    HPRD  PubMed  
    P61964 Q03164 MLL    HPRD  PubMed  
    BioGRID:116272 BioGRID:114528 ASH2L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116272 BioGRID:122672 C16orf53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:121709 CHD8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116272 BioGRID:114791 CIAO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:121485 CSRP2BP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:119045 CXXC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:124181 DPY30    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:119582 DTL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:123751 GRWD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:116272 BioGRID:118959 HCFC2    BioGRID  PubMed Co-purification 
    BioGRID:116272 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116272 BioGRID:113946 HIST1H3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:116272 BioGRID:113895 HIST3H3    BioGRID  PubMed Biochemical Activity; Co-crystal Structure; Protein-peptide 
    BioGRID:116272 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116272 BioGRID:129744 KANSL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:113703 KAT6A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:123914 KAT8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:128743 KDM1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:116669 KDM4B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:116272 BioGRID:113246 KDM6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:212433 Kat8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:121570 MAVS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:119612 MBIP    BioGRID  PubMed Two-hybrid 
    BioGRID:116272 BioGRID:110384 MEN1    BioGRID  PubMed Co-purification 
    BioGRID:116272 BioGRID:110443 MLL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex 
    BioGRID:116272 BioGRID:113758 MLL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:115104 MLL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:110444 MLLT1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:116272 BioGRID:117478 MOXD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:115770 MYBBP1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:119980 NLE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:111085 PAFAH1B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:116790 PASK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:111115 PAX7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:116625 PAXIP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:116272 BioGRID:116751 PHF8    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:116272 BioGRID:111308 PIK3CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:111325 PITX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:111456 POU5F1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:116272 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:111678 PSMC5    BioGRID  PubMed Co-localization 
    BioGRID:116272 BioGRID:124760 PYGO2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116272 BioGRID:111864 RBBP5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-purification; Protein-peptide; Reconstituted Complex 
    BioGRID:116272 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:115088 SETD1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:116702 SETD1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:114805 SNRNP40    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:113010 TP53    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116272 BioGRID:113039 TRAF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116272 BioGRID:120877 WDR12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:123195 WDR26    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:131531 WDR53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:122841 WDR59    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:120039 WDR5B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:123255 WDR61    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:123245 WDR82    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116272 BioGRID:121994 ZNF335    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116272 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3-K4 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4-K16 acetylation IDA
    Inferred from Direct Assay
    more info
     
    histone H4-K5 acetylation IDA
    Inferred from Direct Assay
    more info
     
    histone H4-K8 acetylation IDA
    Inferred from Direct Assay
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
     
    histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 5
    Names
    WD repeat-containing protein 5
    WD-repeat protein 5
    BMP2-induced 3-kb gene protein
    SWD3, Set1c WD40 repeat protein, homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017588.2NP_060058.1  WD repeat-containing protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. The two variants encode the same protein.
      Source sequence(s)
      AA490313, AK000552, BC029769, BG773451
      Consensus CDS
      CCDS6981.1
      UniProtKB/Swiss-Prot
      P61964
      Related
      ENSP00000351446, OTTHUMP00000162494, ENST00000358625, OTTHUMT00000254621
      Conserved Domains (1) summary
      cd00200
      Location:37331
      Blast Score: 707
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_052821.3NP_438172.1  WD repeat-containing protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. The two variants encode the same protein.
      Source sequence(s)
      AA490313, AJ011376, AK000552, BC029769
      Consensus CDS
      CCDS6981.1
      UniProtKB/Swiss-Prot
      P61964
      Related
      ENSP00000401889, ENST00000425041
      Conserved Domains (1) summary
      cd00200
      Location:37331
      Blast Score: 707
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      137001210..137025094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      106494213..106518092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BX649632.2 CAI18774.1
    genomic CH471090.1 EAW88117.1
      EAW88118.1
      EAW88119.1
      EAW88120.1
    mRNA AA490313.1 None
    mRNA AJ011376.1 CAB66159.1
    mRNA AK000552.1 BAA91248.1
    mRNA AK024484.1 BAB15774.1
    mRNA AK025810.1 None
    mRNA BC001635.1 AAH01635.1
    mRNA BC015594.1 None
    mRNA BC029769.1 None
    mRNA BG773451.1 None
    other-genetic HQ448239.1 ADQ32719.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61964.1 GenPept UniProtKB/Swiss-Prot:P61964
    Q9H7J6 GenPept UniProtKB/TrEMBL:Q9H7J6

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