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Ppp2r4 protein phosphatase 2A activator, regulatory subunit B [ Mus musculus (house mouse) ]

Gene ID: 110854, updated on 21-May-2016
Official Symbol
Ppp2r4provided by MGI
Official Full Name
protein phosphatase 2A activator, regulatory subunit Bprovided by MGI
Primary source
MGI:MGI:1346006
See related
Ensembl:ENSMUSG00000039515 Vega:OTTMUSG00000016797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR53; C77440; N28142; 2610042B21Rik
Orthologs
Location:
2 B; 2 21.71 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (30416050..30447807)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (30271570..30303327)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 73, member B Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene predicted gene, 31291 Neighboring gene immediate early response 5-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
    Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
  • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling Pathway, organism-specific biosystem
    IL-6 signaling Pathway
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC7129, MGC60706

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphatase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase type 2A regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphatase type 2A regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein tyrosine phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
mitotic spindle organization in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serine/threonine-protein phosphatase 2A activator
Names
PP2A, subunit B', PR53 isoform
PTPA
phosphotyrosyl phosphatase activator
protein phosphatase 2A, regulatory subunit B (PR 53)
serine/threonine-protein phosphatase 2A regulatory subunit 4
serine/threonine-protein phosphatase 2A regulatory subunit B'
NP_620087.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138748.5NP_620087.3  serine/threonine-protein phosphatase 2A activator

    See identical proteins and their annotated locations for NP_620087.3

    Status: VALIDATED

    Source sequence(s)
    AK049184, AL954299
    Consensus CDS
    CCDS15883.1
    UniProtKB/Swiss-Prot
    P58389
    UniProtKB/TrEMBL
    Q543N6
    Related
    ENSMUSP00000046837, OTTMUSP00000018234, ENSMUST00000042055, OTTMUST00000040773
    Conserved Domains (1) summary
    cd04087
    Location:47312
    PTPA; Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    30416050..30447807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497608.1XP_006497671.1  

    Conserved Domains (1) summary
    cd04087
    Location:47230
    PTPA; Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    30120848..30152502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)