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ESM1 endothelial cell specific molecule 1 [ Homo sapiens (human) ]

Gene ID: 11082, updated on 26-May-2016
Official Symbol
ESM1provided by HGNC
Official Full Name
endothelial cell specific molecule 1provided by HGNC
Primary source
HGNC:HGNC:3466
See related
Ensembl:ENSG00000164283 HPRD:03310; MIM:601521; Vega:OTTHUMG00000097010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
endocan
Summary
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Orthologs
Location:
5q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (54977867..54985586, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54273695..54281414, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase like domain containing 1 pseudogene Neighboring gene uncharacterized LOC105378970 Neighboring gene uncharacterized LOC102467081 Neighboring gene granzyme K

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of endothelial cell-specific molecule 1 (ESM1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

  • Gastric cancer network 1, organism-specific biosystem (from WikiPathways)
    Gastric cancer network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hepatocyte growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
endothelial cell-specific molecule 1
Names
ESM-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135604.1NP_001129076.1  endothelial cell-specific molecule 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001129076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC010436, AK300634
    Consensus CDS
    CCDS47206.1
    UniProtKB/Swiss-Prot
    Q9NQ30
    Related
    ENSP00000370810, OTTHUMP00000221554, ENST00000381403, OTTHUMT00000367875
    Conserved Domains (1) summary
    smart00121
    Location:26100
    IB; Insulin growth factor-binding protein homologues
  2. NM_007036.4NP_008967.1  endothelial cell-specific molecule 1 isoform a precursor

    See identical proteins and their annotated locations for NP_008967.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC010436, AK311817
    Consensus CDS
    CCDS3963.1
    UniProtKB/Swiss-Prot
    Q9NQ30
    Related
    ENSP00000370812, OTTHUMP00000122501, ENST00000381405, OTTHUMT00000214099
    Conserved Domains (1) summary
    smart00121
    Location:26100
    IB; Insulin growth factor-binding protein homologues

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    54977867..54985586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    54276642..54284361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)