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    CHD4 chromodomain helicase DNA binding protein 4 [ Homo sapiens ]

    Gene ID: 1108, updated on 11-May-2012

    Summary

    Official Symbol
    CHD4provided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 4provided by HGNC
    Primary source
    HGNC:1919
    See related
    Ensembl:ENSG00000111642; HPRD:04472; MIM:603277; Vega:OTTHUMG00000169164
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mi-2b; Mi2-BETA; DKFZp686E06161
    Summary
    The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    12p13
    Sequence :
    Chromosome: 12; NC_000012.11 (6679248..6716551, complement)
    See CHD4 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene NOP2 nucleolar protein homolog (yeast) Neighboring gene uncharacterized LOC100127974 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene acrosin binding protein

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q14839 Q13535 ATR    HPRD  PubMed  
    Q14839 Q09472 EP300    HPRD  PubMed  
    Q14839 Q13547 HDAC1    HPRD  PubMed  
    Q14839 Zinc finger protein, subfamily 1A, member 4 IKZF4    HPRD  PubMed  
    Q14839 P51449 RORC    HPRD  PubMed  
    Q14839 P51532 SMARCA4    HPRD  PubMed  
    Q14839 P14373 TRIM27    HPRD  PubMed  
    Q14839 Q8IZH2 XRN1    HPRD  PubMed  
    BioGRID:107533 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107533 BioGRID:107027 ATR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:119737 BCL11A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:122343 BCL11B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:117036 BRD4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:117030 CBX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:117504 CHD5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:122097 DPEP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:122099 DPEP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:120172 GATAD2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:121529 GATAD2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107533 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:113946 HIST1H3A    BioGRID  PubMed Co-crystal Structure; Protein-peptide 
    BioGRID:107533 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:115604 IKZF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:116485 IKZF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:116484 IKZF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:122146 IKZF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:110039 KPNA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:117163 KPNA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:119788 MBD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:125944 MBD3L2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107533 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:110446 MLLT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:121568 MTA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:110746 NAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:110747 NAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:114654 NOLC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:116446 PARK7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:111146 PCNT    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107533 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107533 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107533 BioGRID:114346 SAP30    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:112211 SATB1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107533 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107533 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:112489 SMARCE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107533 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107533 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107533 BioGRID:124390 UBASH3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:113190 UBTF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:121651 USP36    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107533 BioGRID:119970 XRN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107533 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent DNA helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chromodomain-helicase-DNA-binding protein 4
    Names
    chromodomain-helicase-DNA-binding protein 4
    CHD-4
    ATP-dependent helicase CHD4
    Mi-2 autoantigen 218 kDa protein
    NP_001264.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001273.2NP_001264.2  chromodomain-helicase-DNA-binding protein 4

      Status: REVIEWED

      Source sequence(s)
      AK128741, BC014964, BC038596
      Consensus CDS
      CCDS8552.1
      UniProtKB/TrEMBL
      B3KY63
      UniProtKB/TrEMBL
      Q05CG6
      UniProtKB/Swiss-Prot
      Q14839
      Related
      ENSP00000349508, ENST00000357008
      Conserved Domains (9) summary
      cd00024
      Location:619674
      Blast Score: 116
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:746904
      Blast Score: 201
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10641172
      Blast Score: 255
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam06461
      Location:13681523
      Blast Score: 679
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam08073
      Location:163217
      Blast Score: 261
      CHDNT; CHDNT (NUC034) domain
      pfam06465
      Location:13081348
      Blast Score: 188
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08074
      Location:17241896
      Blast Score: 826
      CHDCT2; CHDCT2 (NUC038) domain
      PLN03142
      Location:7241281
      Blast Score: 1147
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cl15348
      Location:451495
      Blast Score: 187
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      6679248..6716551, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      6533326..6569829, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006064.10 (127161..164464) None
    genomic CH471116.2 EAW88777.1
      EAW88778.1
      EAW88779.1
    mRNA AK128741.1 BAG54725.1
    mRNA BC014964.1 AAH14964.1
    mRNA BC025962.1 AAH25962.1
    mRNA BC038596.1 AAH38596.1
    mRNA CR936680.1 None
    mRNA X86691.1 CAA60384.1
    other-genetic EU446505.1 ABZ92034.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05CG6 GenPept UniProtKB/TrEMBL:Q05CG6
    Q14839.2 GenPept UniProtKB/Swiss-Prot:Q14839

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