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CHD4 chromodomain helicase DNA binding protein 4 [ Homo sapiens (human) ]

Gene ID: 1108, updated on 26-May-2016
Official Symbol
CHD4provided by HGNC
Official Full Name
chromodomain helicase DNA binding protein 4provided by HGNC
Primary source
HGNC:HGNC:1919
See related
Ensembl:ENSG00000111642 HPRD:04472; MIM:603277; Vega:OTTHUMG00000169164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHD-4; Mi-2b; Mi2-BETA
Summary
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Orthologs
Location:
12p13
Exon count:
40
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (6570082..6607439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6679248..6716551, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene NOP2 nucleolar protein Neighboring gene uncharacterized LOC105369630 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene uncharacterized LOC105369629 Neighboring gene uncharacterized LOC105369631 Neighboring gene lysophosphatidic acid receptor 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, organism-specific biosystem (from REACTOME)
    ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, organism-specific biosystemAbout half of the rRNA genes in the genome are actively expressed, being transcribed by RNA polymerase I (reviewed in Nemeth and Langst 2008, Bartova et al. 2010, Goodfellow and Zomerdijk 2012, Grumm...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • HDACs deacetylate histones, organism-specific biosystem (from REACTOME)
    HDACs deacetylate histones, organism-specific biosystemLysine deacetylases (KDACs), historically referred to as histone deacetylases (HDACs), are divided into the Rpd3/Hda1 metal-dependent 'classical HDAC family' (de Ruijter et al. 2003, Verdin et al. 2...
  • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
  • RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Promoter Clearance, organism-specific biosystemPromoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
  • RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Transcription, organism-specific biosystemThe rRNA genes are transcribed by RNA polymerase I, one of three eukaryotic nuclear RNA polymerases. The polymerase is a multisubunit complex, composed of two large subunits (the most conserved porti...
  • RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Transcription Initiation, organism-specific biosystemDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymeras...
  • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemTranscription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686E06161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase activity TAS
Traceable Author Statement
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleosomal DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
spindle assembly IEA
Inferred from Electronic Annotation
more info
 
terminal button organization IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
chromodomain-helicase-DNA-binding protein 4
Names
ATP-dependent helicase CHD4
Mi-2 autoantigen 218 kDa protein
NP_001264.2
NP_001284482.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001273.3NP_001264.2  chromodomain-helicase-DNA-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001264.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA099889, AC006064, BC038596, BP234473, X86691
    Consensus CDS
    CCDS8552.1
    UniProtKB/Swiss-Prot
    Q14839
    Related
    ENSP00000349508, ENST00000357008
    Conserved Domains (11) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13781523
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17241896
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15831658
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
  2. NM_001297553.1NP_001284482.1  chromodomain-helicase-DNA-binding protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001284482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC006064, BC038596, CR936680, X86691
    Consensus CDS
    CCDS76510.1
    UniProtKB/Swiss-Prot
    Q14839
    UniProtKB/TrEMBL
    F5GWX5
    Conserved Domains (11) summary
    cd00024
    Location:612667
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10571165
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13711516
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:156210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17171889
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15761651
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    6570082..6607439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718962.1XP_006719025.1  

    Conserved Domains (11) summary
    cd00024
    Location:606661
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:733891
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10511159
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7161012
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13651510
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12891339
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17131886
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15701647
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:359401
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
  2. XM_006718960.1XP_006719023.1  

    Conserved Domains (11) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13771522
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13011351
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17251898
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15821659
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
  3. XM_006718959.1XP_006719022.1  

    Conserved Domains (11) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13781523
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17261899
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15831660
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
  4. XM_006718958.1XP_006719021.1  

    UniProtKB/Swiss-Prot
    Q14839
    Related
    ENSP00000440392, OTTHUMP00000240273, ENST00000544484, OTTHUMT00000402631
    Conserved Domains (11) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:14061551
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17521924
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:16111686
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:372414
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:451493
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
  5. XM_005253668.3XP_005253725.1  

    See identical proteins and their annotated locations for XP_005253725.1

    UniProtKB/TrEMBL
    F5GWX5
    Related
    ENSP00000440542, OTTHUMP00000240274, ENST00000544040, OTTHUMT00000402632
    Conserved Domains (11) summary
    cd00024
    Location:612667
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10571165
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13711516
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:156210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17171889
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15761651
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
  6. XM_006718961.2XP_006719024.1  

    Conserved Domains (11) summary
    cd00024
    Location:612667
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10571165
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam06461
    Location:13711516
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:156210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17191892
    CHDCT2; CHDCT2 (NUC038) domain
    pfam14962
    Location:15761653
    AIF-MLS; Mitochondria Localisation Sequence
    cd15531
    Location:365407
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:444486
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    6678251..6715604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)