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TOPBP1 topoisomerase (DNA) II binding protein 1 [ Homo sapiens (human) ]

Gene ID: 11073, updated on 18-Aug-2014
Official Symbol
TOPBP1provided by HGNC
Official Full Name
topoisomerase (DNA) II binding protein 1provided by HGNC
Primary source
HGNC:17008
See related
Ensembl:ENSG00000163781; HPRD:09678; MIM:607760; Vega:OTTHUMG00000159773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOP2BP1
Summary
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
See TOPBP1 in Epigenomics, MapViewer
Location:
3q22.1
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (133600605..133661918, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133319449..133380762, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MAF1 homolog (S. cerevisiae) pseudogene Neighboring gene CDV3 homolog (mouse) Neighboring gene transferrin pseudogene 1 Neighboring gene acyl-CoA synthetase long-chain family member 3 pseudogene Neighboring gene transferrin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia PubMed
env Interactions between tumor suppressor protein PML, TopBP1 and ATM exhibit in HIV-1 Env-elicited syncytia PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IDA
Inferred from Direct Assay
more info
 
condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA topoisomerase 2-binding protein 1
Names
DNA topoisomerase 2-binding protein 1
DNA topoisomerase II-binding protein 1
DNA topoisomerase II-beta-binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007027.3NP_008958.2  DNA topoisomerase 2-binding protein 1

    See proteins identical to NP_008958.2

    Status: REVIEWED

    Source sequence(s)
    BC032633, BC126209, BC151237
    Consensus CDS
    CCDS46919.1
    UniProtKB/TrEMBL
    A0AV47
    UniProtKB/TrEMBL
    A7E2X7
    UniProtKB/TrEMBL
    Q05BV8
    UniProtKB/Swiss-Prot
    Q92547
    Related
    ENSP00000260810, OTTHUMP00000216435, ENST00000260810, OTTHUMT00000357254
    Conserved Domains (2) summary
    cd00027
    Location:202272
    Blast Score: 157
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00533
    Location:550620
    Blast Score: 97
    BRCT; BRCA1 C Terminus (BRCT) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    133600605..133661918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247076.1XP_005247133.1  

    Conserved Domains (2) summary
    cd00027
    Location:202272
    Blast Score: 157
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00533
    Location:545615
    Blast Score: 97
    BRCT; BRCA1 C Terminus (BRCT) domain

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    130698929..130760396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    133282831..133344118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)