These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001005271.2 → NP_001005271.2 chromodomain-helicase-DNA-binding protein 3 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and CDS, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct N-terminus, compared to isoform 1. The transcript is supported by ESTs and an mRNA but the predicted protein has not yet been confirmed experimentally.
- Source sequence(s)
-
AF064844, AK125928, BC110648, BX283837, CB851648, U91543
- Consensus CDS
-
CCDS32553.2
- UniProtKB/TrEMBL
-
B3KWV4
- UniProtKB/TrEMBL
-
E9PG89
- UniProtKB/Swiss-Prot
-
Q12873
- UniProtKB/TrEMBL
-
Q2TAZ1
- Related
- ENSP00000369716, OTTHUMP00000197337, ENST00000380358, OTTHUMT00000318052
- Conserved Domains (9) summary
-
- cd00024
Location:687 – 742
Blast Score: 122
- CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
- cd00046
Location:815 – 973
Blast Score: 211
- DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
- cd00079
Location:1133 – 1241
Blast Score: 248
- HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
- pfam06461
Location:1444 – 1576
Blast Score: 595
- DUF1086; Domain of Unknown Function (DUF1086)
- pfam08073
Location:206 – 260
Blast Score: 267
- CHDNT; CHDNT (NUC034) domain
- pfam06465
Location:1371 – 1416
Blast Score: 194
- DUF1087; Domain of Unknown Function (DUF1087)
- pfam08074
Location:1794 – 1966
Blast Score: 876
- CHDCT2; CHDCT2 (NUC038) domain
- PLN03142
Location:778 – 1332
Blast Score: 1168
- PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
- cl15348
Location:440 – 482
Blast Score: 176
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
-
NM_001005273.2 → NP_001005273.1 chromodomain-helicase-DNA-binding protein 3 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1.
- Source sequence(s)
-
AK125928, BC110648, CB851648, U91543
- Consensus CDS
-
CCDS32554.1
- UniProtKB/TrEMBL
-
B3KWV4
- UniProtKB/Swiss-Prot
-
Q12873
- UniProtKB/TrEMBL
-
Q2TAZ1
- Related
- ENSP00000332628, OTTHUMP00000197335, ENST00000330494, OTTHUMT00000318050
- Conserved Domains (9) summary
-
- cd00024
Location:628 – 683
Blast Score: 121
- CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
- cd00046
Location:756 – 914
Blast Score: 211
- DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
- cd00079
Location:1074 – 1182
Blast Score: 248
- HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
- pfam06461
Location:1385 – 1517
Blast Score: 595
- DUF1086; Domain of Unknown Function (DUF1086)
- pfam08073
Location:147 – 201
Blast Score: 267
- CHDNT; CHDNT (NUC034) domain
- pfam06465
Location:1312 – 1357
Blast Score: 194
- DUF1087; Domain of Unknown Function (DUF1087)
- pfam08074
Location:1735 – 1907
Blast Score: 876
- CHDCT2; CHDCT2 (NUC038) domain
- PLN03142
Location:719 – 1273
Blast Score: 1167
- PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
- cl15348
Location:381 – 423
Blast Score: 176
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
-
NM_005852.3 → NP_005843.2 chromodomain-helicase-DNA-binding protein 3 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
- Source sequence(s)
-
AK125928, BC110648, CB851648, U91543
- Consensus CDS
-
CCDS32555.1
- UniProtKB/TrEMBL
-
B3KWV4
- UniProtKB/Swiss-Prot
-
Q12873
- UniProtKB/TrEMBL
-
Q2TAZ1
- Related
- ENSP00000350907, OTTHUMP00000197336, ENST00000358181, OTTHUMT00000318051
- Conserved Domains (9) summary
-
- cd00024
Location:628 – 683
Blast Score: 122
- CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
- cd00046
Location:756 – 914
Blast Score: 211
- DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
- cd00079
Location:1074 – 1182
Blast Score: 248
- HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
- pfam06461
Location:1385 – 1517
Blast Score: 597
- DUF1086; Domain of Unknown Function (DUF1086)
- pfam08073
Location:147 – 201
Blast Score: 267
- CHDNT; CHDNT (NUC034) domain
- pfam06465
Location:1312 – 1357
Blast Score: 195
- DUF1087; Domain of Unknown Function (DUF1087)
- pfam08074
Location:1701 – 1873
Blast Score: 876
- CHDCT2; CHDCT2 (NUC038) domain
- PLN03142
Location:719 – 1273
Blast Score: 1171
- PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
- cl15348
Location:381 – 423
Blast Score: 176
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000017.10 Reference GRCh37.p5 Primary Assembly
- Range
- 7788123..7816075
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000149.1 Alternate HuRef
- Range
- 7683207..7710664
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)