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    Aldh7a1 aldehyde dehydrogenase family 7, member A1 [ Mus musculus (house mouse) ]

    Gene ID: 110695, updated on 11-May-2013
    Official Symbol
    Aldh7a1provided by MGI
    Official Full Name
    aldehyde dehydrogenase family 7, member A1provided by MGI
    Primary source
    MGI:108186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atq1; D18Wsu181e
    Location :
    18 D3; 18 30.55 cM
    Sequence :
    Chromosome: 18; NC_000084.6 (56525736..56572939, complement)
    See Aldh7a1 in Epigenomics, MapViewer

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 3 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene RIKEN cDNA 1700065I17 gene Neighboring gene phosphorylated adaptor for RNA export Neighboring gene lamin B1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    2. Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. Brocker C, et al. J Biol Chem, 2010 Jun 11. PMID 20207735.
    3. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Levi BP, et al. Blood, 2009 Feb 19. PMID 18971422.
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015.

    See all (28) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes
      Title: Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.
    2. The expression intensity for the aldehyde dehydrogenase 7A1 (ALDH7A1) mRNA and protein was significantly higher in C57BL/6 mice than DBA/2 mice.
      Title: Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-aminoadipate-semialdehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    aldehyde dehydrogenase (NAD) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    betaine-aldehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    alpha-aminoadipic semialdehyde dehydrogenase
    Names
    alpha-aminoadipic semialdehyde dehydrogenase
    antiquitin-1
    P6c dehydrogenase
    alpha-AASA dehydrogenase
    betaine aldehyde dehydrogenase
    aldehyde dehydrogenase 7 family, member A1
    delta1-piperideine-6-carboxylate dehydrogenase
    delta1-piperideine-6-carboxylate dehydrogenease
    NP_001120810.1
    NP_613066.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127338.1 → NP_001120810.1  alpha-aminoadipic semialdehyde dehydrogenase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK004991, CJ156580
      Consensus CDS
      CCDS50291.1
      UniProtKB/Swiss-Prot
      Q9DBF1
      Conserved Domains (2) summary
      cd07130
      Location:25 – 499
      Blast Score: 2429
      ALDH_F7_AASADH; NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B
      PLN02315
      Location:9 – 510
      Blast Score: 1879
      PLN02315; aldehyde dehydrogenase family 7 member

    2. NM_138600.4 → NP_613066.2  alpha-aminoadipic semialdehyde dehydrogenase isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK004991, AK169195, BY017676
      Consensus CDS
      CCDS29258.2
      UniProtKB/Swiss-Prot
      Q9DBF1
      Conserved Domains (2) summary
      cd07130
      Location:53 – 527
      Blast Score: 2433
      ALDH_F7_AASADH; NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B
      PLN02315
      Location:37 – 538
      Blast Score: 1883
      PLN02315; aldehyde dehydrogenase family 7 member

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p1 C57BL/6J

      Range
      56525736..56572939, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      57828935..57877977, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01138949.1 None
    genomic AAHY01138950.1 None
    genomic AAHY01138951.1 None
    genomic AAHY01138952.1 (31228..35119) None
    genomic AC162035.5 (75138..122274) None
    genomic CH466528.2 EDL09878.1 mixed
      EDL09879.1 mixed
      EDL09880.1 mixed
      EDL09881.1 mixed
      EDL09882.1 mixed
      EDL09883.1 mixed
      EDL09884.1 mixed
    mRNA AK004991.1 BAB23726.1 C57BL/6J
    mRNA AK145873.1 BAE26715.1 C57BL/6J
    mRNA AK160117.1 BAE35641.1 C57BL/6J
    mRNA AK169195.1 BAE40971.1 C57BL/6J
    mRNA AK187582.1 None
    mRNA AK189373.1 None
    mRNA AK198202.1 None
    mRNA AK215603.1 None
    mRNA BC012407.1 AAH12407.1 FVB/N
    mRNA BY017676.1 None
    mRNA CJ156580.1 None C57BL/6J
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBF1.4 GenPept UniProtKB/Swiss-Prot:Q9DBF1

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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