UBE2C ubiquitin-conjugating enzyme E2C [Homo sapiens] - Gene

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Summary

Official Symbol: UBE2Cprovided by HGNC
Official Full Name: ubiquitin-conjugating enzyme E2Cprovided by HGNC
Primary source: HGNC:15937
Locus tag: RP3-447F3.1
See related: Ensembl:ENSG00000175063; HPRD:05717; MIM:605574; Vega:OTTHUMG00000033038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UBCH10; dJ447F3.2
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

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Genomic context

Location :: 20q13.12

Sequence :: Chromosome: 20; NC_000020.10 (44441255..44445596)

See UBE2C in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UbcH10 expression was associated with tumor invasion of the portal vein, tumor size, TNM staging, and tumor differentiation in hepatocellular carcinoma.
Title: [UbcH10 expression in hepatocellular carcinoma and its clinicopathological significance].
Effect of UBE2C overexpression on the proliferation of 293T cell line
Title: [Effect of UBE2C overexpression on the proliferation of 293T cell line].
Mediator complex subunit (MED)1 phosphorylation leads to UBE2C locus looping, UBE2C gene expression and cell growth in castration-resistant prostate cancer.
Title: Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.
Title: Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.
Elevated expression of UbcH10 is associated with breast cancer.
Title: Clinicopathological relevance of UbcH10 in breast cancer.
elevated levels of Ubch10 and Cdc20 degrade cyclin B in hpv-16 iinfected cells, required for exit from mitosis, permitting initiation of the next round of DNA synthesis and cell cycle progression.
Title: Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
The unstructured N-terminal region of UbcH10 directly binds the 19 S regulatory complex of the 26 S proteasome, and it mediates the initiation of substrate translocation.
Title: Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates.
The overexpression of UbcH10 gene plays a critical role in the carcinogenesis and tumor progression of colorectal cancer.
Title: Association of clinicopathological features with UbcH10 expression in colorectal cancer.

Submit: New GeneRIF Correction See all (26)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O00762	Q9NYG5	ANAPC11	HPRD	PubMed
O00762	Q9UJX6	ANAPC2	HPRD	PubMed
O00762	P09104	ENO2	HPRD	PubMed
O00762	O00762	UBE2C	HPRD	PubMed
BioGRID:116249	BioGRID:118937	ANAPC2	BioGRID	PubMed	Co-fractionation; Reconstituted Complex
BioGRID:116249	BioGRID:107166	BUB1B	BioGRID	PubMed	Co-fractionation
BioGRID:116249	BioGRID:107427	CDC20	BioGRID	PubMed	Co-fractionation
BioGRID:116249	BioGRID:108173	DTX1	BioGRID	PubMed	Two-hybrid
BioGRID:116249	BioGRID:108340	ENO2	BioGRID	PubMed	Two-hybrid
BioGRID:116249	BioGRID:110260	MAD2L1	BioGRID	PubMed	Co-fractionation
BioGRID:116249	BioGRID:118168	POLM	BioGRID	PubMed	Biochemical Activity
BioGRID:116249	BioGRID:119981	RNF216	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116249	BioGRID:124390	UBASH3B	BioGRID	PubMed	Biochemical Activity
BioGRID:116249	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:116249	BioGRID:124656	UBE3D	BioGRID	PubMed	Reconstituted Complex
BioGRID:116249	BioGRID:212952	Ube2c	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
acid-amino acid ligase activity	IEA Inferred from Electronic Annotation more info
ligase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info
contributes_to ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
activation of anaphase-promoting complex activity	TAS Traceable Author Statement more info	PubMed
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info
cell cycle	NAS Non-traceable Author Statement more info	PubMed
cell cycle checkpoint	TAS Traceable Author Statement more info
cell division	IEA Inferred from Electronic Annotation more info
cyclin catabolic process	IDA Inferred from Direct Assay more info	PubMed
exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
free ubiquitin chain polymerization	IDA Inferred from Direct Assay more info	PubMed
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	TAS Traceable Author Statement more info
mitotic cell cycle spindle assembly checkpoint	TAS Traceable Author Statement more info
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS Traceable Author Statement more info
phosphatidylinositol-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS Traceable Author Statement more info
protein K11-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info
protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS Traceable Author Statement more info
spindle organization	NAS Non-traceable Author Statement more info	PubMed
ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
nucleoplasm	TAS Traceable Author Statement more info

General protein information

Preferred Names: ubiquitin-conjugating enzyme E2 C

Names: ubiquitin-conjugating enzyme E2 C; ubiquitin-protein ligase C; ubiquitin carrier protein C; ubiquitin carrier protein E2-C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme

NP_008950.1

EC 6.3.2.19

NP_861515.1

EC 6.3.2.19

NP_861516.1

EC 6.3.2.19

NP_861517.1

EC 6.3.2.19

NP_861518.1

EC 6.3.2.19

NP_861519.1

EC 6.3.2.19

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007019.2 → NP_008950.1 ubiquitin-conjugating enzyme E2 C isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BM747513, U73379

Consensus CDS

CCDS13370.1

UniProtKB/Swiss-Prot

O00762

UniProtKB/TrEMBL

Q5TZN3

Related

ENSP00000348838, OTTHUMP00000031653, ENST00000356455, OTTHUMT00000080309

Conserved Domains (1) summary

cd00195
Location:33 – 170
Blast Score: 446

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_181799.1 → NP_861515.1 ubiquitin-conjugating enzyme E2 C isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate internal exon, as compared to variant 1. It encodes isoform 2, which differs from isoform 1 in the middle sequence region.

Source sequence(s)

BM556795, BM747513, U73379

Consensus CDS

CCDS13371.1

UniProtKB/TrEMBL

G3XAB7

UniProtKB/Swiss-Prot

O00762

Related

ENSP00000335674, OTTHUMP00000031654, ENST00000335046, OTTHUMT00000080311

Conserved Domains (1) summary

cl00154
Location:33 – 152
Blast Score: 168

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_181800.1 → NP_861516.1 ubiquitin-conjugating enzyme E2 C isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal exon, as compared to variant 1. It encodes isoform 3, which lacks a middle region, as compared to isoform 1.

Source sequence(s)

BM747513, BU844974, U73379

Consensus CDS

CCDS13372.1

UniProtKB/TrEMBL

A6NP33

UniProtKB/Swiss-Prot

O00762

Related

ENSP00000333975, OTTHUMP00000196691, ENST00000352551, OTTHUMT00000316950

Conserved Domains (1) summary

cd00195
Location:44 – 141
Blast Score: 321

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_181801.2 → NP_861517.1 ubiquitin-conjugating enzyme E2 C isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. It uses a downstream start codon and encodes isoform 4, which has a shorter N-terminus than that of isoform 1.

Source sequence(s)

BC007656, BI858659, BP227692

Consensus CDS

CCDS13374.1

UniProtKB/TrEMBL

E1P5N7

UniProtKB/Swiss-Prot

O00762

Related

ENSP00000361649, OTTHUMP00000031655, ENST00000372568, OTTHUMT00000080312

Conserved Domains (1) summary

cd00195
Location:1 – 131
Blast Score: 400

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_181802.1 → NP_861518.1 ubiquitin-conjugating enzyme E2 C isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an additional segment in the 5' region, as compared to variant 1. It uses a downstream start codon and encodes isoform 4, which has a shorter N-terminus than that of isoform 1.

Source sequence(s)

BC028161, BM747513

Consensus CDS

CCDS13374.1

UniProtKB/TrEMBL

E1P5N7

Related

ENSP00000385878, ENST00000405520

Conserved Domains (1) summary

cd00195
Location:1 – 131
Blast Score: 400

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_181803.1 → NP_861519.1 ubiquitin-conjugating enzyme E2 C isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two internal exons, as compared to variant 1. It encodes isoform 5, which lacks the middle and C-terminal regions but has an alternate C-terminus that is shorter than that of isoform 1.

Source sequence(s)

BM747513, CB143441

Consensus CDS

CCDS13373.1

Related

ENSP00000243893, OTTHUMP00000196690, ENST00000243893, OTTHUMT00000316949

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

44441255..44445596

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

41183027..41187357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL050348.22 (82274..86615)	None
genomic	CH471077.2	EAW75804.1
		EAW75805.1
		EAW75806.1
		EAW75807.1
		EAW75808.1
		EAW75809.1
mRNA	AK311949.1	BAG34890.1
mRNA	BC007656.2	AAH07656.1
mRNA	BC016292.1	AAH16292.1
mRNA	BC028161.1	None
mRNA	BC032677.2	None
mRNA	BC050736.1	AAH50736.1
mRNA	BF974975.1	None
mRNA	BI858659.1	None
mRNA	BM556795.1	None
mRNA	BM747513.1	None
mRNA	BP227692.1	None
mRNA	BT007300.1	AAP35964.1
mRNA	BT020165.1	AAV38967.1
mRNA	BT020166.1	AAV38968.1
mRNA	BU844974.1	None
mRNA	CB143441.1	None
mRNA	CR456988.1	CAG33269.1
mRNA	U73379.1	AAB53362.1
other-genetic	BT007515.1	AAP36183.1
other-genetic	DQ892416.2	ABM83342.1
other-genetic	DQ895630.2	ABM86556.1
other-genetic	EU831629.1	ACE87229.1
other-genetic	EU831714.1	ACE86548.1