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PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Neomonachus schauinslandi (Hawaiian monk seal) ]

Gene ID: 110591287, updated on 15-Mar-2024

Summary

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Gene symbol
PIK3R1
Gene description
phosphoinositide-3-kinase regulatory subunit 1
See related
EnsemblRapid:ENSNSCG00000016785
Gene type
protein coding
RefSeq status
MODEL
Organism
Neomonachus schauinslandi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Neomonachus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
17
Annotation release Status Assembly Chr Location
101 current ASM220157v2 (GCF_002201575.2) 7 NC_058409.1 (49279197..49353364)
100 previous assembly ASM220157v1 (GCF_002201575.1) Unplaced Scaffold NW_018734388.1 (42637807..42711976)

Chromosome 7 - NC_058409.1Genomic Context describing neighboring genes Neighboring gene B-cell CLL/lymphoma 9 protein-like Neighboring gene RNA-binding motif, single-stranded-interacting protein 2-like Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene solute carrier family 30 member 5 Neighboring gene cyclin B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neomonachus schauinslandi Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM220157v2

Genomic

  1. NC_058409.1 Reference ASM220157v2

    Range
    49279197..49353364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021702168.2 → XP_021557843.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2Y9I1U1
    Related
    ENSNSCP00000021004.1
    Conserved Domains (5) summary
    cd09930
    Location:618 → 721
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 436
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:441 → 601
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:116 → 303
    RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

  2. XM_021702169.2 → XP_021557844.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A2Y9I6H0
    Conserved Domains (3) summary
    cd09930
    Location:449 → 552
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:157 → 267
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:272 → 432
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  3. XM_044916869.1 → XP_044772804.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8M1MPX6
    Conserved Domains (3) summary
    cd09930
    Location:288 → 391
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:170 → 271
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. XM_021702170.2 → XP_021557845.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A2Y9I8L3
    Related
    ENSNSCP00000021038.1
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  5. XM_044916868.1 → XP_044772803.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8M1MJI6
    Conserved Domains (3) summary
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cl15255
    Location:336 → 393
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
Heading Accession and Version

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