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TNK2 tyrosine kinase non receptor 2 [ Neomonachus schauinslandi (Hawaiian monk seal) ]

Gene ID: 110582698, updated on 15-Mar-2024

Summary

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Gene symbol
TNK2
Gene description
tyrosine kinase non receptor 2
See related
EnsemblRapid:ENSNSCG00000023404
Gene type
protein coding
RefSeq status
MODEL
Organism
Neomonachus schauinslandi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Neomonachus
Orthologs
human mouse all
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Genomic context

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See TNK2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
20
Annotation release Status Assembly Chr Location
101 current ASM220157v2 (GCF_002201575.2) 1 NC_058403.1 (69489620..69536950, complement)
100 previous assembly ASM220157v1 (GCF_002201575.1) Unplaced Scaffold NW_018734347.1 (18192004..18239336)

Chromosome 1 - NC_058403.1Genomic Context describing neighboring genes Neighboring gene mucin 4, cell surface associated Neighboring gene EKC/KEOPS complex subunit LAGE3-like Neighboring gene transferrin receptor Neighboring gene zinc finger DHHC-type palmitoyltransferase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
activated CDC42 kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neomonachus schauinslandi Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM220157v2

Genomic

  1. NC_058403.1 Reference ASM220157v2

    Range
    69489620..69536950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021692695.1 → XP_021548370.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9HG82
    Related
    ENSNSCP00000029687.1, ENSNSCT00000033394.1
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:978 → 1021
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1008 → 1047
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:791 → 855
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:594 → 859
    Atrophin-1; Atrophin-1 family

  2. XM_021692700.1 → XP_021548375.1  activated CDC42 kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A2Y9HFD8
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:113 → 370
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:378 → 427
    SH3_9; Variant SH3 domain
    pfam09027
    Location:430 → 497
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:577 → 842
    Atrophin-1; Atrophin-1 family

  3. XM_021692701.1 → XP_021548376.1  activated CDC42 kinase 1 isoform X10

    UniProtKB/TrEMBL
    A0A2Y9H9G5
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:948 → 991
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:978 → 1017
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:761 → 825
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:594 → 950
    Atrophin-1; Atrophin-1 family

  4. XM_021692694.1 → XP_021548369.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9HG82
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:978 → 1021
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1008 → 1047
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:791 → 855
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:594 → 859
    Atrophin-1; Atrophin-1 family

  5. XM_021692696.1 → XP_021548371.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9HG82
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:978 → 1021
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1008 → 1047
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain
    pfam09027
    Location:447 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:791 → 855
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:594 → 859
    Atrophin-1; Atrophin-1 family

  6. XM_044919811.1 → XP_044775746.1  activated CDC42 kinase 1 isoform X11

    UniProtKB/TrEMBL
    A0A8M1MPG7
    Conserved Domains (5) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:417 → 468
    SH3; Src homology 3 domains
    PHA03247
    Location:603 → 868
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:985 → 1024
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  7. XM_044919789.1 → XP_044775724.1  activated CDC42 kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M1MXX5
    Conserved Domains (6) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:417 → 468
    SH3; Src homology 3 domains
    PHA03247
    Location:603 → 868
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:987 → 1030
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1017 → 1056
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  8. XM_044919799.1 → XP_044775734.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M1MXY0
    Conserved Domains (5) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:417 → 468
    SH3; Src homology 3 domains
    PHA03247
    Location:618 → 883
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:1000 → 1039
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  9. XM_044919786.1 → XP_044775721.1  activated CDC42 kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M1MPE1
    Conserved Domains (6) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:417 → 468
    SH3; Src homology 3 domains
    PHA03247
    Location:618 → 883
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1002 → 1045
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1032 → 1071
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  10. XM_044919798.1 → XP_044775733.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M1MSQ2
    Conserved Domains (5) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:425 → 476
    SH3; Src homology 3 domains
    PHA03247
    Location:626 → 891
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:1008 → 1047
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  11. XM_044919783.1 → XP_044775718.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1MSN7
    Conserved Domains (6) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:425 → 476
    SH3; Src homology 3 domains
    PHA03247
    Location:626 → 891
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1010 → 1053
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1040 → 1079
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  12. XM_021692706.1 → XP_021548381.1  activated CDC42 kinase 1 isoform X9

    UniProtKB/TrEMBL
    A0A2Y9H9G8
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14328
    Location:993 → 1032
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:808 → 872
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    cl26464
    Location:611 → 876
    Atrophin-1; Atrophin-1 family

  13. XM_044919787.1 → XP_044775722.1  activated CDC42 kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M1MPF2
    Conserved Domains (6) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:425 → 476
    SH3; Src homology 3 domains
    PHA03247
    Location:611 → 876
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:995 → 1038
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1025 → 1064
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
Nucleotide Protein
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