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LRP6 LDL receptor related protein 6 [ Lonchura striata domestica (Bengalese finch) ]

Gene ID: 110472952, updated on 15-Mar-2024

Summary

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Gene symbol
LRP6
Gene description
LDL receptor related protein 6
Locus tag
RLOC_00013896
See related
Ensembl:ENSLSDG00000017839
Gene type
protein coding
RefSeq status
MODEL
Organism
Lonchura striata domestica (sub-species: domestica)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae; Estrildinae; Lonchura
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1A
Exon count:
24
Annotation release Status Assembly Chr Location
101 current lonStrDom2 (GCF_005870125.1) 1A NC_042566.1 (51900621..52023363, complement)
100 previous assembly LonStrDom1 (GCF_002197715.1) Unplaced Scaffold NW_018656392.1 (3190383..3315039)

Chromosome 1A - NC_042566.1Genomic Context describing neighboring genes Neighboring gene cystine/glutamate transporter Neighboring gene protein mono-ADP-ribosyltransferase PARP12 Neighboring gene MANSC domain containing 1 Neighboring gene BLOC-1 related complex subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 6
Names
Low-density lipoprotein receptor-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Lonchura striata domestica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference lonStrDom2 Primary Assembly

Genomic

  1. NC_042566.1 Reference lonStrDom2 Primary Assembly

    Range
    51900621..52023363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021535114.2 → XP_021390789.1  low-density lipoprotein receptor-related protein 6 isoform X2

    Conserved Domains (6) summary
    smart00135
    Location:397 → 437
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1274 → 1308
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:55 → 93
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:150 → 190
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:55 → 158
    NHL; NHL repeat unit of beta-propeller proteins
    pfam14670
    Location:286 → 323
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_021535113.2 → XP_021390788.1  low-density lipoprotein receptor-related protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A218V8V8
    Related
    ENSLSDP00000025508.1
    Conserved Domains (6) summary
    smart00135
    Location:397 → 437
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1288 → 1322
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:55 → 93
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:150 → 190
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl18310
    Location:55 → 158
    NHL; NHL repeat unit of beta-propeller proteins
    pfam14670
    Location:286 → 323
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_021535117.2 → XP_021390792.1  low-density lipoprotein receptor-related protein 6 isoform X3

    Conserved Domains (4) summary
    smart00135
    Location:246 → 286
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1137 → 1171
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:1 → 39
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:135 → 172
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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