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ADRM1 adhesion regulating molecule 1 [ Homo sapiens (human) ]

Gene ID: 11047, updated on 20-May-2016
Official Symbol
ADRM1provided by HGNC
Official Full Name
adhesion regulating molecule 1provided by HGNC
Primary source
HGNC:HGNC:15759
See related
Ensembl:ENSG00000130706 HPRD:06440; MIM:610650; Vega:OTTHUMG00000032904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARM1; ARM-1; GP110
Summary
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Orthologs
Location:
20q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (62302056..62308862)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60877112..60884206)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein FLJ44790 Neighboring gene oxysterol binding protein like 2 Neighboring gene uncharacterized LOC105372707 Neighboring gene laminin subunit alpha 5 Neighboring gene microRNA 4758 Neighboring gene LAMA5 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC29536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
proteasome assembly IDA
Inferred from Direct Assay
more info
PubMed 
transcription elongation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
proteasomal ubiquitin receptor ADRM1
Names
110 kDa cell membrane glycoprotein
M(r) 110,000 surface antigen
proteasome regulatory particle non-ATPase 13
rpn13 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050661.1 RefSeqGene

    Range
    5841..11807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281437.1NP_001268366.1  proteasomal ubiquitin receptor ADRM1 isoform 2

    See identical proteins and their annotated locations for NP_001268366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    BC017245, BR000321, HY029018, HY178253
    Consensus CDS
    CCDS74747.1
    UniProtKB/Swiss-Prot
    Q16186
    UniProtKB/TrEMBL
    A0A087WX59
    Conserved Domains (1) summary
    cl17171
    Location:2489
    PH-like; Pleckstrin homology-like domain
  2. NM_001281438.1NP_001268367.1  proteasomal ubiquitin receptor ADRM1 isoform 2

    See identical proteins and their annotated locations for NP_001268367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    BC017245, BG337785, BR000321, HY029018
    Consensus CDS
    CCDS74747.1
    UniProtKB/Swiss-Prot
    Q16186
    UniProtKB/TrEMBL
    A0A087WX59
    Related
    ENSP00000480756, ENST00000620230
    Conserved Domains (1) summary
    cl17171
    Location:2489
    PH-like; Pleckstrin homology-like domain
  3. NM_007002.3NP_008933.2  proteasomal ubiquitin receptor ADRM1 isoform 1

    See identical proteins and their annotated locations for NP_008933.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC017245, BR000321, HY029018
    Consensus CDS
    CCDS13496.1
    UniProtKB/Swiss-Prot
    Q16186
    Related
    ENSP00000253003, ENST00000253003
    Conserved Domains (1) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
  4. NM_175573.2NP_783163.1  proteasomal ubiquitin receptor ADRM1 isoform 1

    See identical proteins and their annotated locations for NP_783163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC017245, BR000321, HY029018
    Consensus CDS
    CCDS13496.1
    UniProtKB/Swiss-Prot
    Q16186
    Conserved Domains (1) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    62302056..62308862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260257.1XP_005260314.1  

    See identical proteins and their annotated locations for XP_005260314.1

    UniProtKB/Swiss-Prot
    Q16186
    Related
    ENSP00000478877, OTTHUMP00000031471, ENST00000491935, OTTHUMT00000080007
    Conserved Domains (1) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
  2. XM_011528503.1XP_011526805.1  

    Conserved Domains (1) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
  3. XM_011528502.1XP_011526804.1  

    See identical proteins and their annotated locations for XP_011526804.1

    UniProtKB/Swiss-Prot
    Q16186
    Conserved Domains (1) summary
    cd13314
    Location:24128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    60778716..60784682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)