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    GTF2A1L general transcription factor IIA, 1-like [ Homo sapiens ]

    Gene ID: 11036, updated on 11-May-2012

    Summary

    Official Symbol
    GTF2A1Lprovided by HGNC
    Official Full Name
    general transcription factor IIA, 1-likeprovided by HGNC
    Primary source
    HGNC:30727
    See related
    Ensembl:ENSG00000068781; Ensembl:ENSG00000242441; HPRD:05640; MIM:605358; Vega:OTTHUMG00000152038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALF; MGC26254
    Summary
    The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    2p16.3
    Sequence :
    Chromosome: 2; NC_000002.11 (48844937..48906748)
    See GTF2A1L in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 21 Neighboring gene STON1-GTF2A1L readthrough Neighboring gene FLJ46838 protein Neighboring gene stonin 1 Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene C-terminal binding protein 2 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UNN4 Q9NQ33 ASCL3    HPRD  PubMed  
    Q9UNN4 P68400 CSNK2A1    HPRD  PubMed  
    Q9UNN4 P19784 CSNK2A2    HPRD  PubMed  
    Q9UNN4 P52657 GTF2A2    HPRD  PubMed  
    Q9UNN4 Q02535 ID3    HPRD  PubMed  
    Q9UNN4 P53999 SUB1    HPRD  PubMed  
    BioGRID:116225 BioGRID:106958 ATF4    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:107482 CEBPE    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:108331 EMX1    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:108333 EMX2    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:115643 HMG20A    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:109442 HOXA5    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:109467 HOXC11    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:109465 HOXC9    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:117264 MAFF    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:110272 MAFG    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:127740 NKX2-3    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:111117 PAX9    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:117087 RBFOX2    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:111034 SIX6    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116225 BioGRID:109436 TLX2    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:119030 TLX3    BioGRID  PubMed Two-hybrid 
    BioGRID:116225 BioGRID:122933 ZBTB3    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Readthrough STON1-GTF2A1L

    Readthrough gene: STON1-GTF2A1L, Included gene: STON1

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor TFIIA complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TFIIA-alpha and beta-like factor
    Names
    TFIIA-alpha and beta-like factor
    GTF2A1-like factor
    TFIIA-alpha/beta-like factor
    TFIIA large subunit isoform ALF
    general transcription factor II A, 1-like factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193487.1NP_001180416.1  TFIIA-alpha and beta-like factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK302220, BG207854
      Consensus CDS
      CCDS54359.1
      UniProtKB/Swiss-Prot
      Q9UNN4
      Related
      ENSP00000387896, ENST00000430487
      Conserved Domains (2) summary
      cd07976
      Location:387444
      Blast Score: 269
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      pfam03153
      Location:8444
      Blast Score: 600
      TFIIA; Transcription factor IIA, alpha/beta subunit
    2. NM_006872.3NP_006863.2  TFIIA-alpha and beta-like factor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK302220, BC025991, BG207854
      Consensus CDS
      CCDS46281.1
      UniProtKB/Swiss-Prot
      Q9UNN4
      Related
      ENSP00000384597, OTTHUMP00000201062, ENST00000403751, OTTHUMT00000323852
      Conserved Domains (2) summary
      cd07976
      Location:421478
      Blast Score: 267
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      pfam03153
      Location:9478
      Blast Score: 753
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      48844937..48906748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      48578316..48640115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172196.1: Suppressed sequence

      Description
      NM_172196.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073082.6 (2000..86689) None
    genomic AC087816.4 (35826..66475) None
    genomic CH471053.2 EAX00193.1
      EAX00194.1
    mRNA AF106857.1 AAD39634.1
    mRNA AI037906.1 None
    mRNA AK223350.1 BAD97070.1
    mRNA AK302220.1 BAG63576.1
    mRNA BC025991.1 AAH25991.1
    mRNA BC064585.1 AAH64585.1
    mRNA BG207854.1 None
    mRNA BG717289.1 None
    other-genetic DQ891566.2 ABM82492.1
    other-genetic DQ894756.2 ABM85682.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNN4.2 GenPept UniProtKB/Swiss-Prot:Q9UNN4

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