Krt7 keratin 7 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Krt7provided by MGI
Official Full Name: keratin 7provided by MGI
Primary source: MGI:96704
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K7; Krt2-7; D15Wsu77e

Genomic context

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Location :: 15 F2; 15 56.88 cM

Sequence :: Chromosome: 15; NC_000081.6 (101412403..101427806)

See Krt7 in Epigenomics, MapViewer

Chromosome 15 - NC_000081.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The -0.25 kb region of keratin 7 promoter showed pancreatic selectivity, high activity in pancreatic cancers, & sustained transgene expression in xenografts. krt7 promoter is useful to target pancreatic ductal adenocarcinoma cells in vitro and in vivo.
Title: Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:225484	BioGRID:234431	Nphp4		BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

D15Wsu77e (e-PCR), detects polymorphism
- UniSTS:142032

Homology

Homologs of the Krt7 gene: The Krt7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Map Viewer (Human, Rat)

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Golgi apparatus	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
intermediate filament	IEA Inferred from Electronic Annotation more info
keratin filament	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 7

Names: keratin, type II cytoskeletal 7; CK-7; keratin-7; sarcolectin; Cytokeratin 7; cytokeratin-7; type-II keratin Kb7; keratin complex 2, basic, gene 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033073.3 → NP_149064.1 keratin, type II cytoskeletal 7

Status: VALIDATED

Source sequence(s)

AC157583, AK146914, BU755120

Consensus CDS

CCDS27851.1

UniProtKB/Swiss-Prot

Q9DCV7

Conserved Domains (1) summary

pfam00038
Location:89 – 396
Blast Score: 1035

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000081.6 Reference GRCm38.p1 C57BL/6J

Range

101412403..101427806

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000037.1 Alternate Mm_Celera

Range

103560951..103576262

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01125121.1 (19066..24249)	None
genomic	AAHY01125122.1 (11758..21865)	None
genomic	AC157583.9 (135891..151281)	None
genomic	AF509890.1	AAN64034.1	129/SvJ
genomic	CH466550.2	EDL04046.1	mixed
		EDL04047.1	mixed
		EDL04048.1	mixed
		EDL04049.1	mixed
mRNA	AF509888.1	AAN64032.1	129/SvJ
mRNA	AK002434.1	BAB22099.1	C57BL/6J
mRNA	AK137217.1	BAE23275.1	C57BL/6J
mRNA	AK146914.1	BAE27526.1	C57BL/6J
mRNA	BC010337.1	None	FVB/N
mRNA	BC030403.1	AAH30403.1	FVB/N
mRNA	BU755120.1	None	C57BL/6J