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Tjp2 tight junction protein 2 [ Mus caroli (Ryukyu mouse) ]

Gene ID: 110285404, updated on 15-Mar-2024

Summary

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Gene symbol
Tjp2
Gene description
tight junction protein 2
See related
Ensembl:MGP_CAROLIEiJ_G0022828
Gene type
protein coding
RefSeq status
MODEL
Organism
Mus caroli
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
29
Annotation release Status Assembly Chr Location
101 current CAROLI_EIJ_v1.1 (GCF_900094665.1) 19 NC_034588.1 (21248423..21379955, complement)

Chromosome 19 - NC_034588.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115029978 Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene E3 ubiquitin-protein ligase NRDP1 pseudogene Neighboring gene frataxin Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_034588.1 Chromosome 19 Reference CAROLI_EIJ_v1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mus caroli Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CAROLI_EIJ_v1.1 Primary Assembly

Genomic

  1. NC_034588.1 Reference CAROLI_EIJ_v1.1 Primary Assembly

    Range
    21248423..21379955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029472523.1 → XP_029328383.1  tight junction protein ZO-2 isoform X8

    UniProtKB/TrEMBL
    A0A6P7QHM3

  2. XM_021151538.2 → XP_021007197.1  tight junction protein ZO-2 isoform X5

    UniProtKB/TrEMBL
    A0A6P5NVE2
    Conserved Domains (4) summary
    cd12027
    Location:607 → 669
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:705 → 884
    GuKc; Guanylate kinase homologues
    smart00228
    Location:311 → 388
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. XM_029472520.1 → XP_029328380.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A6P7QUJ9

  4. XM_029472524.1 → XP_029328384.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A6P5P464
    Related
    MGP_CAROLIEiJ_P0048410, MGP_CAROLIEiJ_T0048410.1
    Conserved Domains (4) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682 → 861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  5. XM_021151541.2 → XP_021007200.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A6P5P464
    Conserved Domains (4) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682 → 861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_029472522.1 → XP_029328382.1  tight junction protein ZO-2 isoform X7

    UniProtKB/TrEMBL
    A0A6P7QJ45

  7. XM_021151540.2 → XP_021007199.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A6P5P464
    Conserved Domains (4) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682 → 861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  8. XM_021151537.2 → XP_021007196.1  tight junction protein ZO-2 isoform X3

    UniProtKB/TrEMBL
    A0A6P5P0W1
    Conserved Domains (4) summary
    cd12027
    Location:618 → 680
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:716 → 895
    GuKc; Guanylate kinase homologues
    smart00228
    Location:322 → 399
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:43 → 128
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  9. XM_021151536.2 → XP_021007195.1  tight junction protein ZO-2 isoform X2

    UniProtKB/TrEMBL
    A0A6P5P0J2
    Conserved Domains (4) summary
    cd12027
    Location:625 → 687
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:723 → 902
    GuKc; Guanylate kinase homologues
    smart00228
    Location:329 → 406
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:50 → 135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  10. XM_029472521.1 → XP_029328381.1  tight junction protein ZO-2 isoform X6

    UniProtKB/TrEMBL
    A0A6P7QRU8
Nucleotide Protein
Heading Accession and Version

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