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LILRA3 leukocyte immunoglobulin like receptor A3 [ Homo sapiens (human) ]

Gene ID: 11026, updated on 15-May-2016
Official Symbol
LILRA3provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A3provided by HGNC
Primary source
HGNC:HGNC:6604
See related
HPRD:10382; MIM:604818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
Summary
This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
Orthologs
See LILRA3 in Map Viewer
Location:
19q13.4
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 (ALT_REF_LOCI_9) NT_187693.1 (270964..281078, complement)
107 current GRCh38.p2 (GCF_000001405.28) 19 (ALT_REF_LOCI_1) NW_003571054.1 (270735..280849, complement)
107 current GRCh38.p2 (GCF_000001405.28) 19 (ALT_REF_LOCI_2) NW_003571055.2 (270616..280731, complement)
107 current GRCh38.p2 (GCF_000001405.28) 19 (ALT_REF_LOCI_8) NW_003571061.2 (270991..275406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54799854..54804625, complement)

NW_003571054.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene YME1 like 1 ATPase pseudogene Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

NW_003571055.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin-like receptor subfamily B member 3 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

NW_003571061.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

NT_187693.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding TAS
Traceable Author Statement
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 3
Names
CD85 antigen-like family member E
immunoglobulin-like transcript 6
leucocyte Ig-like receptor A3
leukocyte immunoglobulin-like receptor 4
leukocyte immunoglobulin-like receptor A3
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
monocyte inhibitory receptor HM43/HM31

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034046.1 RefSeqGene

    Range
    5001..9416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172654.2NP_001166125.1  leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001166125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF014924, AI655471, BX280714
    UniProtKB/Swiss-Prot
    Q8N6C8
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:271333
    IG_like; Immunoglobulin like
    cl11960
    Location:261355
    Ig; Immunoglobulin domain
  2. NM_006865.4NP_006856.3  leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006856.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF014923, AF025527, AI655471
    UniProtKB/Swiss-Prot
    Q8N6C8
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    270735..280849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547085.1XP_011545387.1  

    Conserved Domains (3) summary
    cd05751
    Location:88180
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:396458
    IG_like; Immunoglobulin like
    cl11960
    Location:185280
    Ig; Immunoglobulin domain
  2. XM_011547086.1XP_011545388.1  

    See identical proteins and their annotated locations for XP_011545388.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:363425
    IG_like; Immunoglobulin like
    cl11960
    Location:353447
    Ig; Immunoglobulin domain
  3. XM_011547084.1XP_011545386.1  

    See identical proteins and their annotated locations for XP_011545386.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain
  4. XM_011547082.1XP_011545384.1  

    See identical proteins and their annotated locations for XP_011545384.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain
  5. XM_011547083.1XP_011545385.1  

    See identical proteins and their annotated locations for XP_011545385.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain
  6. XM_011547088.1XP_011545390.1  

    See identical proteins and their annotated locations for XP_011545390.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:363425
    IG_like; Immunoglobulin like
    cl11960
    Location:353447
    Ig; Immunoglobulin domain
  7. XM_011547087.1XP_011545389.1  

    See identical proteins and their annotated locations for XP_011545389.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    270616..280731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005277092.3XP_005277149.1  

    See identical proteins and their annotated locations for XP_005277149.1

    UniProtKB/Swiss-Prot
    Q8N6C8
    Conserved Domains (3) summary
    cd05751
    Location:44136
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:352414
    IG_like; Immunoglobulin like
    cl11960
    Location:141236
    Ig; Immunoglobulin domain
  2. XM_011547505.1XP_011545807.1  

    Conserved Domains (3) summary
    cd05751
    Location:88180
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:396458
    IG_like; Immunoglobulin like
    cl11960
    Location:185280
    Ig; Immunoglobulin domain
  3. XM_011547506.1XP_011545808.1  

    See identical proteins and their annotated locations for XP_011545808.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:363425
    IG_like; Immunoglobulin like
    cl11960
    Location:353447
    Ig; Immunoglobulin domain
  4. XM_011547503.1XP_011545805.1  

    See identical proteins and their annotated locations for XP_011545805.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain
  5. XM_011547507.1XP_011545809.1  

    See identical proteins and their annotated locations for XP_011545809.1

    UniProtKB/Swiss-Prot
    Q8N6C8
    Conserved Domains (3) summary
    cd05751
    Location:44136
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:352414
    IG_like; Immunoglobulin like
    cl11960
    Location:141236
    Ig; Immunoglobulin domain
  6. XM_011547504.1XP_011545806.1  

    See identical proteins and their annotated locations for XP_011545806.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p2 ALT_REF_LOCI_8

    Range
    270991..275406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p2 ALT_REF_LOCI_9

    Range
    270964..281078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548675.1XP_011546977.1  

    See identical proteins and their annotated locations for XP_011546977.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:363425
    IG_like; Immunoglobulin like
    cl11960
    Location:353447
    Ig; Immunoglobulin domain
  2. XM_011548674.1XP_011546976.1  

    See identical proteins and their annotated locations for XP_011546976.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain
  3. XM_011548673.1XP_011546975.1  

    See identical proteins and their annotated locations for XP_011546975.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain
  4. XM_011548677.1XP_011546979.1  

    See identical proteins and their annotated locations for XP_011546979.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:363425
    IG_like; Immunoglobulin like
    cl11960
    Location:353447
    Ig; Immunoglobulin domain
  5. XM_011548676.1XP_011546978.1  

    See identical proteins and their annotated locations for XP_011546978.1

    Conserved Domains (3) summary
    cd05751
    Location:119211
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:427489
    IG_like; Immunoglobulin like
    cl11960
    Location:216311
    Ig; Immunoglobulin domain