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Tmbim6 transmembrane BAX inhibitor motif containing 6 [ Mus musculus (house mouse) ]

Gene ID: 110213, updated on 8-May-2016
Official Symbol
Tmbim6provided by MGI
Official Full Name
transmembrane BAX inhibitor motif containing 6provided by MGI
Primary source
MGI:MGI:99682
See related
Ensembl:ENSMUSG00000023010 Vega:OTTMUSG00000034310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bi1; Tegt; 5031406P05Rik
Orthologs
Location:
15 56.13 cM; 15 F3
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (99392947..99410049)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99223378..99240480)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene formin-like 3 Neighboring gene uncharacterized LOC102637966 Neighboring gene NCK-associated protein 5-like Neighboring gene predicted gene, 34594

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endoribonuclease inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoribonuclease inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immunoglobulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to L-glutamate ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
bax inhibitor 1
Names
BI-1
testis enhanced gene transcript
testis-enhanced gene transcript protein
transmembrane BAX inhibitor motif-containing protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171034.1NP_001164505.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_001164505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK036782, AK139901, BE990530, BY272301, CD554385
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q9D2C7
    Related
    ENSMUSP00000125563, OTTMUSP00000047362, ENSMUST00000161250, OTTMUST00000087290
    Conserved Domains (1) summary
    cd10430
    Location:16228
    BI-1; BAX inhibitor (BI)-1
  2. NM_001171035.1NP_001164506.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_001164506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK036782, AK139901, BE990530, BY158276, BY753376
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q9D2C7
    Related
    ENSMUSP00000125117, OTTMUSP00000047365, ENSMUST00000159209, OTTMUST00000087293
    Conserved Domains (1) summary
    cd10430
    Location:16228
    BI-1; BAX inhibitor (BI)-1
  3. NM_001171036.1NP_001164507.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_001164507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AC118646, AK036782, AK139901, BE990530, BY272301
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q9D2C7
    Related
    ENSMUSP00000124651, OTTMUSP00000047363, ENSMUST00000160635, OTTMUST00000087291
    Conserved Domains (1) summary
    cd10430
    Location:16228
    BI-1; BAX inhibitor (BI)-1
  4. NM_026669.4NP_080945.1  bax inhibitor 1

    See identical proteins and their annotated locations for NP_080945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK036782, AK139901, BE990530, BY272301
    Consensus CDS
    CCDS37201.1
    UniProtKB/Swiss-Prot
    Q9D2C7
    Related
    ENSMUSP00000023749, OTTMUSP00000047360, ENSMUST00000023749, OTTMUST00000087288
    Conserved Domains (1) summary
    cd10430
    Location:16228
    BI-1; BAX inhibitor (BI)-1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    99392947..99410049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    101548094..101565263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)