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Fgb fibrinogen beta chain [ Mus musculus (house mouse) ]

Gene ID: 110135, updated on 8-May-2016
Official Symbol
Fgbprovided by MGI
Official Full Name
fibrinogen beta chainprovided by MGI
Primary source
MGI:MGI:99501
See related
Ensembl:ENSMUSG00000033831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510049G14Rik
Summary
This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]
Orthologs
Location:
3 E3; 3 36.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (83042303..83049790, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (82846225..82853712, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene fibrinogen alpha chain Neighboring gene predicted gene, 40075 Neighboring gene pleiotropic regulator 1 Neighboring gene predicted gene 10710 Neighboring gene protocadherin alpha 5 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
contributes_to receptor binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
induction of bacterial agglutination ISO
Inferred from Sequence Orthology
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
protein polymerization ISO
Inferred from Sequence Orthology
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
fibrinogen complex ISO
Inferred from Sequence Orthology
more info
 
platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
fibrinogen beta chain
Names
fibrinogen, B beta polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181849.3NP_862897.1  fibrinogen beta chain preproprotein

    See identical proteins and their annotated locations for NP_862897.1

    Status: REVIEWED

    Source sequence(s)
    AC138394, AK168626, AW110458
    Consensus CDS
    CCDS17432.1
    UniProtKB/Swiss-Prot
    Q8K0E8
    UniProtKB/TrEMBL
    Q3TGR2
    Related
    ENSMUSP00000039472, OTTMUSP00000069935, ENSMUST00000048246, OTTMUST00000130537
    Conserved Domains (2) summary
    pfam08702
    Location:80225
    Fib_alpha; Fibrinogen alpha/beta chain family
    cd00087
    Location:228477
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    83042303..83049790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    83046408..83053935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)