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SLC27A5 solute carrier family 27 member 5 [ Homo sapiens (human) ]

Gene ID: 10998, updated on 12-May-2016
Official Symbol
SLC27A5provided by HGNC
Official Full Name
solute carrier family 27 member 5provided by HGNC
Primary source
HGNC:HGNC:10999
See related
Ensembl:ENSG00000083807 HPRD:04499; MIM:603314; Vega:OTTHUMG00000183543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2
Summary
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19q13.43
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (58498333..58512065, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59009700..59023432, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324 Neighboring gene zinc finger protein 446 Neighboring gene uncharacterized LOC105372485 Neighboring gene uncharacterized LOC105372486 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene tripartite motif containing 28 Neighboring gene microRNA 6807

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cholate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid transporter activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
bile acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
bile acid biosynthetic process TAS
Traceable Author Statement
more info
 
ketone body biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
plasma membrane long-chain fatty acid transport IEA
Inferred from Electronic Annotation
more info
 
triglyceride mobilization IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
bile acyl-CoA synthetase
Names
BA-CoA ligase
VLACS-related
bile acid-CoA ligase
cholate--CoA ligase
fatty acid transport protein 5
fatty-acid-Coenzyme A ligase, very long-chain 3
solute carrier family 27 (fatty acid transporter), member 5
very long-chain acyl-CoA synthetase homolog 2
very long-chain acyl-CoA synthetase-related protein
NP_036386.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047124.1 RefSeqGene

    Range
    5001..18733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321196.1NP_001308125.1  bile acyl-CoA synthetase isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AF064255, AK123036, AK298446, BU688212
    Conserved Domains (1) summary
    cl17068
    Location:146596
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_012254.2NP_036386.1  bile acyl-CoA synthetase isoform 1 precursor

    See identical proteins and their annotated locations for NP_036386.1

    Status: REVIEWED

    Source sequence(s)
    AK123036, BX103174
    Consensus CDS
    CCDS12983.1
    UniProtKB/Swiss-Prot
    Q9Y2P5
    Related
    ENSP00000263093, OTTHUMP00000271930, ENST00000263093, OTTHUMT00000467060
    Conserved Domains (2) summary
    cd05938
    Location:140680
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:87690
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    58498333..58512065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526364.1XP_011524666.1  

    Conserved Domains (2) summary
    pfam00501
    Location:120558
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:140592
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_011526363.1XP_011524665.1  

    UniProtKB/Swiss-Prot
    Q9Y2P5
    Related
    ENSP00000470368, OTTHUMP00000271931, ENST00000601355, OTTHUMT00000467061
    Conserved Domains (1) summary
    cl17068
    Location:146596
    AFD_class_I; Adenylate forming domain, Class I superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    59003732..59017394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)