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SDS serine dehydratase [ Homo sapiens (human) ]

Gene ID: 10993, updated on 7-May-2016
Official Symbol
SDSprovided by HGNC
Official Full Name
serine dehydrataseprovided by HGNC
Primary source
HGNC:HGNC:10691
See related
Ensembl:ENSG00000135094 HPRD:01633; MIM:182128; Vega:OTTHUMG00000169554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDH
Summary
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q24.13
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (113392445..113403887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113830250..113841692, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene uncharacterized LOC105369989 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase like Neighboring gene LHX5 antisense RNA 1 (head to head) Neighboring gene LIM homeobox 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
    Biosynthesis of amino acids, organism-specific biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Biosynthesis of amino acids, conserved biosystem (from KEGG)
    Biosynthesis of amino acids, conserved biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
    Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Cysteine and methionine metabolism, conserved biosystem (from KEGG)
    Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Glycine, serine and threonine metabolism, organism-specific biosystem (from KEGG)
    Glycine, serine and threonine metabolism, organism-specific biosystemSerine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In ...
  • Glycine, serine and threonine metabolism, conserved biosystem (from KEGG)
    Glycine, serine and threonine metabolism, conserved biosystemSerine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In ...
  • L-serine degradation, conserved biosystem (from BIOCYC)
    L-serine degradation, conserved biosystemThe L-serine degradation pathway consists of a single enzymatic reaction, catalyzed by |FRAME: EC-4.3.1.17|. The enzyme, which is |FRAME: PYRIDOXAL_PHOSPHATE|-dependent, dehydrates L-serine to the en...
  • L-threonine degradation V, conserved biosystem (from BIOCYC)
    L-threonine degradation V, conserved biosystemGeneral Background |FRAME: THR| is an indispensable amino acid and is degraded by two major degradative pathways in vertebrates. In most vertebrates, the degradation of L-threonine occurs through a ...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Valine, leucine and isoleucine biosynthesis, organism-specific biosystem (from KEGG)
    Valine, leucine and isoleucine biosynthesis, organism-specific biosystem
    Valine, leucine and isoleucine biosynthesis
  • Valine, leucine and isoleucine biosynthesis, conserved biosystem (from KEGG)
    Valine, leucine and isoleucine biosynthesis, conserved biosystem
    Valine, leucine and isoleucine biosynthesis
  • threonine degradation, organism-specific biosystem (from BIOCYC)
    threonine degradation, organism-specific biosystemGeneral Background : THR is an indispensable amino acid and is degraded by two major degradative pathways in vertebrates. In most vertebrates, the degradation of L-threonine occurs through a two-ste...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
L-threonine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
L-serine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
pyruvate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
Preferred Names
L-serine dehydratase/L-threonine deaminase
Names
L-serine ammonia-lyase
L-serine deaminase
L-serine dehydratase
L-threonine dehydratase
TDH
NP_006834.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006843.2NP_006834.2  L-serine dehydratase/L-threonine deaminase

    See identical proteins and their annotated locations for NP_006834.2

    Status: REVIEWED

    Source sequence(s)
    BC020750, BG534053, BG566257, BU740747, J05037
    Consensus CDS
    CCDS9169.1
    UniProtKB/Swiss-Prot
    P20132
    UniProtKB/TrEMBL
    Q8WW81
    Related
    ENSP00000257549, OTTHUMP00000241529, ENST00000257549, OTTHUMT00000404790
    Conserved Domains (1) summary
    cd06448
    Location:10320
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    113392445..113403887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    113798461..113809912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)