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Braf Braf transforming gene [ Mus musculus (house mouse) ]

Gene ID: 109880, updated on 22-May-2016
Official Symbol
Brafprovided by MGI
Official Full Name
Braf transforming geneprovided by MGI
Primary source
MGI:MGI:88190
See related
Ensembl:ENSMUSG00000002413 Vega:OTTMUSG00000035245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-raf; Braf2; Braf-2; C87398; AA120551; AA387315; AA473386; C230098H17; D6Ertd631e; 9930012E13Rik
Orthologs
Location:
6 B1; 6 18.43 cM
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (39603231..39725656, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (39553236..39675462, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 Neighboring gene predicted gene, 34389 Neighboring gene ferritin heavy chain, pseudogene 2 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene predicted gene 7554

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor signaling protein activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
face development IGI
Inferred from Genetic Interaction
more info
PubMed 
glucose transport ISO
Inferred from Sequence Orthology
more info
 
head morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon regeneration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
response to cAMP ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase B-raf
Names
B-Raf proto-oncogene serine/threonine-protein kinase (p94)
proto-oncogene B-Raf
NP_647455.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139294.5NP_647455.3  serine/threonine-protein kinase B-raf

    See identical proteins and their annotated locations for NP_647455.3

    Status: VALIDATED

    Source sequence(s)
    AC122345, AC163109, AK140431, BF466677, CK393545
    Consensus CDS
    CCDS39463.1
    UniProtKB/Swiss-Prot
    P28028
    Related
    ENSMUSP00000002487, OTTMUSP00000049160, ENSMUST00000002487, OTTMUST00000089870
    Conserved Domains (4) summary
    cd01816
    Location:140211
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:219264
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:494750
    Pkinase; Protein kinase domain
    cd14062
    Location:500752
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    39603231..39725656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241134.1XP_011239436.1  

    Conserved Domains (4) summary
    cd01816
    Location:250324
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:332377
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:607863
    Pkinase; Protein kinase domain
    cd14062
    Location:613865
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  2. XM_011241135.1XP_011239437.1  

    Conserved Domains (4) summary
    cd01816
    Location:250324
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:332377
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:595851
    Pkinase; Protein kinase domain
    cd14062
    Location:601853
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  3. XM_006505353.2XP_006505416.1  

    Conserved Domains (4) summary
    cd01816
    Location:250321
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:329374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:604860
    Pkinase; Protein kinase domain
    cd14062
    Location:610862
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  4. XM_006505355.2XP_006505418.1  

    Conserved Domains (4) summary
    cd01816
    Location:250321
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:329374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:592848
    Pkinase; Protein kinase domain
    cd14062
    Location:598850
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  5. XM_011241138.1XP_011239440.1  

    Conserved Domains (4) summary
    cd01816
    Location:250324
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:332377
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:567823
    Pkinase; Protein kinase domain
    cd14062
    Location:573825
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  6. XM_011241139.1XP_011239441.1  

    Conserved Domains (4) summary
    cd01816
    Location:250324
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:332377
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:555811
    Pkinase; Protein kinase domain
    cd14062
    Location:561813
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  7. XM_006505358.2XP_006505421.1  

    Conserved Domains (4) summary
    cd01816
    Location:250321
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:329374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:552808
    Pkinase; Protein kinase domain
    cd14062
    Location:558810
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  8. XM_011241137.1XP_011239439.1  

    Conserved Domains (4) summary
    cd01816
    Location:134208
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:216261
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:491747
    Pkinase; Protein kinase domain
    cd14062
    Location:497749
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  9. XM_011241136.1XP_011239438.1  

    Conserved Domains (4) summary
    cd01816
    Location:140214
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:222267
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:497753
    Pkinase; Protein kinase domain
    cd14062
    Location:503755
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  10. XM_006505359.2XP_006505422.1  

    Related
    ENSMUSP00000099036, OTTMUSP00000049161, ENSMUST00000101497, OTTMUST00000089871
    Conserved Domains (4) summary
    cd01816
    Location:250321
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:329374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00069
    Location:552808
    Pkinase; Protein kinase domain
    cd14062
    Location:558810
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
  11. XM_011241140.1XP_011239442.1  

    Conserved Domains (3) summary
    cd01816
    Location:250324
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:332377
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl21453
    Location:598716
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    39588093..39710723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)