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TMED10 transmembrane p24 trafficking protein 10 [ Homo sapiens (human) ]

Gene ID: 10972, updated on 26-May-2016
Official Symbol
TMED10provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 10provided by HGNC
Primary source
HGNC:HGNC:16998
See related
Ensembl:ENSG00000170348 HPRD:12013; MIM:605406; Vega:OTTHUMG00000171771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA)
Summary
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Orthologs
Location:
14q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (75131468..75176646, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75598171..75643349, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene NIMA related kinase 9 Neighboring gene hypoxia inducible factor 1 alpha subunit pseudogene 1 Neighboring gene uncharacterized LOC105370571 Neighboring gene Fos proto-oncogene, AP-1 trancription factor subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with transmembrane emp24-like trafficking protein 10 (TMED10) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Expression of HIV-1 Tat downregulates the abundance of transmembrane emp24-like trafficking protein 10 (TMED10) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
    COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemCOPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles wer...
  • Cargo concentration in the ER, organism-specific biosystem (from REACTOME)
    Cargo concentration in the ER, organism-specific biosystemComputational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, wh...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPI coating of Golgi vesicle TAS
Traceable Author Statement
more info
PubMed 
COPI-coated vesicle budding IDA
Inferred from Direct Assay
more info
PubMed 
COPII vesicle coating TAS
Traceable Author Statement
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Golgi organization IEA
Inferred from Electronic Annotation
more info
 
cargo loading into vesicle TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
protein oligomerization IEA
Inferred from Electronic Annotation
more info
 
regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of beta-amyloid formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to alkaloid IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER ISS
Inferred from Sequence or Structural Similarity
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
vesicle targeting, to, from or within Golgi ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
COPI-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cis-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
gamma-secretase complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-Golgi network transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 
zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
transmembrane emp24 domain-containing protein 10
Names
21 kDa transmembrane trafficking protein
21 kDa transmembrane-trafficking protein
p24 family protein delta-1
p24delta
p24delta1
testicular tissue protein Li 206
transmembrane emp24-like trafficking protein 10
transmembrane protein Tmp21

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006827.5NP_006818.3  transmembrane emp24 domain-containing protein 10 precursor

    See identical proteins and their annotated locations for NP_006818.3

    Status: REVIEWED

    Source sequence(s)
    AK056156, AL832012, BG675810, BX248754, BX504393, CN420777, DB528262, X97442
    Consensus CDS
    CCDS9840.1
    UniProtKB/Swiss-Prot
    P49755
    UniProtKB/TrEMBL
    A0A024R6I3
    Related
    ENSP00000303145, OTTHUMP00000246815, ENST00000303575, OTTHUMT00000415034
    Conserved Domains (1) summary
    pfam01105
    Location:31213
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    75131468..75176646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    75535938..75581127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)