Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    Itga1 integrin alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 109700, updated on 11-May-2013
    Official Symbol
    Itga1provided by MGI
    Official Full Name
    integrin alpha 1provided by MGI
    Primary source
    MGI:96599
    See related
    Ensembl:ENSMUSG00000042284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vla1; CD49A; E130012M19Rik
    Location :
    13 D2.2; 13 64.61 cM
    Sequence :
    Chromosome: 13; NC_000079.6 (114958079..115101964, complement)
    See Itga1 in Epigenomics, MapViewer

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene integrin alpha 2 Neighboring gene ubiquitin-40S ribosomal protein S27a-like Neighboring gene predicted gene 10734 Neighboring gene pelota homolog (Drosophila) Neighboring gene microfibrillar-associated protein 1B pseudogene Neighboring gene ribosomal protein L3 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. TSC2 modulates cell adhesion and migration via integrin-α1β1. Moir LM, et al. Am J Physiol Lung Cell Mol Physiol, 2012 Oct 15. PMID 22923640.
    2. Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Yu L, et al. Kidney Int, 2012 Jun. PMID 22297672.
    3. Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin. Kang S, et al. J Immunol, 2012 Feb 1. PMID 22198947.
    4. Very late antigen-1 mediates corneal lymphangiogenesis. Grimaldo S, et al. Invest Ophthalmol Vis Sci, 2011 Jul 1. PMID 21372020.
    5. Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis. Dennis J, et al. Am J Pathol, 2010 Nov. PMID 20864678.

    See all (83) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TSC2 controls cell migration, attachment, and spreading through the alpha1beta1-integrin receptor.
      Title: TSC2 modulates cell adhesion and migration via integrin-α1β1.
    2. Integrin alpha1KOAkitaKO Balb/c mouse represents a promising model presenting with most features of human diabetic nephropathy.
      Title: Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
    3. Data show that the induction of collagen XIII in endothelial cells of Alport syndrome kidneys mediates the selective recruitment of alpha1beta1 integrin-positive monocytes.
      Title: Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis.
    4. Collectively, our results suggest that vascular basement membrane components substantially impact gene expression in astrocytes during brain tissue repair.
      Title: Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes.
    5. The ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1-dependent Cav-1 expression and consequent EGFR-mediated reactive oxygen species production.
      Title: Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression.
    6. data suggest VLA-1 expression defines a population of tissue memory CD4(+) T cells that act as rapid effectors upon influenza reinfection
      Title: Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
    7. These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment.
      Title: Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
    8. results indicate that loss of integrin alpha1 subunit decreases incidence and growth of lung epithelial tumors initiated by oncogenic Kras, suggesting that both Kras and integrin alpha1beta1 cooperate to drive growth of non-small cell lung cancer in vivo
      Title: Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
    9. Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt.
      Title: Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries.
    10. Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells.
      Title: Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome.
    Submit: New GeneRIF Correction See all (26)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    vasodilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    integrin alpha-1
    Names
    integrin alpha-1
    VLA-1
    laminin and collagen receptor
    CD49 antigen-like family member A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033228.3 → NP_001028400.2  integrin alpha-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK033533, AK035870, AK040830, AK053377
      Consensus CDS
      CCDS36788.1
      UniProtKB/Swiss-Prot
      Q3V3R4
      UniProtKB/TrEMBL
      Q8BPT3
      Related
      ENSMUSP00000077132, ENSMUST00000061673
      Conserved Domains (4) summary
      cd01469
      Location:171 – 351
      Blast Score: 632
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      smart00191
      Location:567 – 620
      Blast Score: 163
      Int_alpha; Integrin alpha (beta-propellor repeats).
      pfam08441
      Location:663 – 1075
      Blast Score: 824
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:579 – 650
      Blast Score: 94
      VCBS; Family description

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p1 C57BL/6J

      Range
      114958079..115101964, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000035.1 Alternate Mm_Celera

      Range
      119308615..119462806, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01110431.1 None
    genomic AAHY01110432.1 None
    genomic AAHY01110433.1 None
    genomic AAHY01110434.1 None
    genomic AAHY01110435.1 None
    genomic AAHY01110436.1 None
    genomic AAHY01110437.1 None
    genomic AAHY01110438.1 None
    genomic AAHY01110439.1 None
    genomic AAHY01110440.1 None
    genomic AAHY01110441.1 None
    genomic AAHY01110442.1 None
    genomic AAHY01110443.1 None
    genomic AAHY01110444.1 None
    genomic AAHY01110445.1 None
    genomic AAHY01110446.1 None
    genomic AAHY01110447.1 None
    genomic AAHY01110448.1 None
    genomic AAHY01110449.1 None
    genomic AAHY01110450.1 None
    genomic AAHY01110451.1 None
    genomic AAHY01110452.1 None
    genomic AAHY01110453.1 None
    genomic AC175538.1 (108268..181760) None
    genomic CT025598.9 (159874..228266) None
    mRNA AK029105.1 None C57BL/6J
    mRNA AK033533.1 None C57BL/6J
    mRNA AK035870.1 BAE20498.1 C57BL/6J
    mRNA AK040830.1 None C57BL/6J
    mRNA AK043769.1 BAE20643.1 C57BL/6J
    mRNA AK053377.1 BAC35370.1 C57BL/6J
    mRNA AK137169.1 None C57BL/6J
    mRNA AK141204.1 BAE24585.1 C57BL/6J
    mRNA AK169964.1 None NOD
    mRNA BC014765.1 AAH14765.1 FVB/N
    mRNA DQ113653.1 None C57BL/6J
    other-genetic BC167237.1 AAI67237.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V3R4.2 GenPept UniProtKB/Swiss-Prot:Q3V3R4

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...