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Top2a DNA topoisomerase II alpha [ Castor canadensis (American beaver) ]

Gene ID: 109694415, updated on 14-Mar-2024

Summary

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Gene symbol
Top2a
Gene description
DNA topoisomerase II alpha
See related
Ensembl:ENSCCNG00000006578
Gene type
protein coding
RefSeq status
MODEL
Organism
Castor canadensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae; Castor
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
36
Annotation release Status Assembly Chr Location
100 current C.can genome v1.0 (GCF_001984765.1) Unplaced Scaffold NW_017871497.1 (496699..524144, complement)

NW_017871497.1Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor alpha Neighboring gene gap junction protein delta 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_017871497.1 Unplaced Scaffold Reference C.can genome v1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 2-alpha
Names
topoisomerase (DNA) II alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Castor canadensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference C.can genome v1.0

Genomic

  1. NW_017871497.1 Reference C.can genome v1.0

    Range
    496699..524144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_020176322.1 → XP_020031911.1  DNA topoisomerase 2-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8B7VIT3, A0A8C0W7X7
    Related
    ENSCCNP00000006304.1, ENSCCNT00000008281.1
    Conserved Domains (1) summary
    PTZ00108
    Location:24 → 1477
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. XM_020176323.1 → XP_020031912.1  DNA topoisomerase 2-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8B7VK60, A0A8C0W7X7
    Conserved Domains (1) summary
    PTZ00108
    Location:24 → 1476
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
Nucleotide Protein
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