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C3 complement C3 [ Castor canadensis (American beaver) ]

Gene ID: 109694300, updated on 14-Mar-2024

Summary

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Gene symbol
C3
Gene description
complement C3
See related
Ensembl:ENSCCNG00000027154
Gene type
protein coding
RefSeq status
MODEL
Organism
Castor canadensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae; Castor
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
41
Annotation release Status Assembly Chr Location
100 current C.can genome v1.0 (GCF_001984765.1) Unplaced Scaffold NW_017871478.1 (58852..87403)

NW_017871478.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 14 Neighboring gene CD70 molecule

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_017871478.1 Unplaced Scaffold Reference C.can genome v1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Castor canadensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference C.can genome v1.0

Genomic

  1. NW_017871478.1 Reference C.can genome v1.0

    Range
    58852..87403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_020176151.1 → XP_020031740.1  complement C3

    UniProtKB/TrEMBL
    A0A8C0XMB0
    Related
    ENSCCNP00000028146.1, ENSCCNT00000035579.1
    Conserved Domains (7) summary
    cd00017
    Location:675 → 745
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:993 → 1279
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03583
    Location:1510 → 1658
    NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
    pfam00207
    Location:768 → 863
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128 → 222
    A2M_N; MG2 domain
    pfam07677
    Location:1395 → 1490
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:453 → 602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein
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