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Arrb1 arrestin, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 109689, updated on 30-May-2016
Official Symbol
Arrb1provided by MGI
Official Full Name
arrestin, beta 1provided by MGI
Primary source
MGI:MGI:99473
See related
Ensembl:ENSMUSG00000018909 Vega:OTTMUSG00000034019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW208571; 1200006I17Rik; G430100A01Rik
Orthologs
Location:
7 E2; 7 54.09 cM
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (99535486..99606772)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (106683996..106755281)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39056 Neighboring gene predicted gene, 40450 Neighboring gene predicted gene, 34172 Neighboring gene nuclear encoded tRNA glutamic acid 3 (anticodon CTC) Neighboring gene microRNA 326 Neighboring gene uncharacterized LOC102637409 Neighboring gene trophoblast glycoprotein-like Neighboring gene solute carrier organic anion transporter family, member 2b1 Neighboring gene predicted gene, 34280

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC124269, MGC124270

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
V2 vasopressin receptor binding ISO
Inferred from Sequence Orthology
more info
 
alpha-1A adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
alpha-1B adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
clathrin adaptor activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
follicle-stimulating hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphorylated amino acid binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
follicle-stimulating hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of G-protein coupled receptor protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
beta-arrestin-1
Names
beta-arrestin1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177231.2NP_796205.1  beta-arrestin-1 isoform A

    See identical proteins and their annotated locations for NP_796205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer protein (isoform A).
    Source sequence(s)
    AK147508, AK147566
    Consensus CDS
    CCDS40032.1
    UniProtKB/Swiss-Prot
    Q8BWG8
    Related
    ENSMUSP00000095866, OTTMUSP00000046443, ENSMUST00000098266, OTTMUST00000085875
    Conserved Domains (2) summary
    smart01017
    Location:193356
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_178220.3NP_835738.1  beta-arrestin-1 isoform B

    See identical proteins and their annotated locations for NP_835738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an alternate exon in the 3' coding region compared to variant a. The resulting protein (isoform B) is shorter but has the same N- and C-termini compared to isoform A.
    Source sequence(s)
    AK090090, AK147508, AK147566
    Consensus CDS
    CCDS21484.1
    UniProtKB/Swiss-Prot
    Q8BWG8
    Related
    ENSMUSP00000032995, OTTMUSP00000046444, ENSMUST00000032995, OTTMUST00000085876
    Conserved Domains (2) summary
    smart01017
    Location:193348
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    99535486..99606772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507198.2XP_006507261.1  

    Conserved Domains (2) summary
    smart01017
    Location:230393
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:55211
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. XM_006507199.2XP_006507262.1  

    Conserved Domains (2) summary
    smart01017
    Location:230385
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:55211
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. XM_006507200.2XP_006507263.1  

    Conserved Domains (2) summary
    smart01017
    Location:188351
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:13169
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_011241644.1XP_011239946.1  

    Conserved Domains (2) summary
    smart01017
    Location:205368
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:30186
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. XR_378207.2 RNA Sequence

  2. XR_378208.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    99859615..99932041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)