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Ampd2 adenosine monophosphate deaminase 2 [ Mus musculus (house mouse) ]

Gene ID: 109674, updated on 28-May-2016
Official Symbol
Ampd2provided by MGI
Official Full Name
adenosine monophosphate deaminase 2provided by MGI
Primary source
MGI:MGI:88016
See related
Ensembl:ENSMUSG00000027889 Vega:OTTMUSG00000007186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ampd-2; AI552571; m4521Dajl; 1200014F01Rik
Orthologs
Location:
3 F2.3; 3 46.83 cM
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (108074061..108086666, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (107876980..107889545, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36498 Neighboring gene glutathione S-transferase, mu 4 Neighboring gene predicted gene 12500 Neighboring gene guanine nucleotide binding protein, alpha transducing 2 Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting 3 Neighboring gene G protein-coupled receptor 61

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AMP deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
AMP deaminase activity ISO
Inferred from Sequence Orthology
more info
 
deaminase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
AMP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTP metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
GTP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
IMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
IMP salvage IEA
Inferred from Electronic Annotation
more info
 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cyclic purine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
 
energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
glomerular visceral epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
purine ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
Preferred Names
AMP deaminase 2
Names
adenosine monophosphate deaminase 2 (isoform L)
NP_001276648.1
NP_001276649.1
NP_083055.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289719.1NP_001276648.1  AMP deaminase 2 isoform b

    See identical proteins and their annotated locations for NP_001276648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK004759, BC049119, CK389537
    Consensus CDS
    CCDS17749.1
    UniProtKB/Swiss-Prot
    Q9DBT5
    Related
    ENSMUSP00000099697, OTTMUSP00000007621, ENSMUST00000102637, OTTMUST00000016581
    Conserved Domains (1) summary
    cd01319
    Location:275771
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
  2. NM_001289720.1NP_001276649.1  AMP deaminase 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK004759, AK034844, BC049119, BY209955
    UniProtKB/Swiss-Prot
    Q9DBT5
    Conserved Domains (1) summary
    cd01319
    Location:301808
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
  3. NM_028779.5NP_083055.1  AMP deaminase 2 isoform b

    See identical proteins and their annotated locations for NP_083055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL671854, BC049119, CK389537
    Consensus CDS
    CCDS17749.1
    UniProtKB/Swiss-Prot
    Q9DBT5
    Related
    ENSMUSP00000099698, OTTMUSP00000007620, ENSMUST00000102638, OTTMUST00000016580
    Conserved Domains (1) summary
    cd01319
    Location:275771
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    108074061..108086666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500868.2XP_006500931.1  

    See identical proteins and their annotated locations for XP_006500931.1

    UniProtKB/TrEMBL
    A2AE27
    Related
    ENSMUSP00000077946, OTTMUSP00000007622, ENSMUST00000078912, OTTMUST00000016582
    Conserved Domains (1) summary
    cd01319
    Location:301797
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
  2. XM_006500871.2XP_006500934.1  

    Conserved Domains (1) summary
    cd01319
    Location:277773
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
  3. XM_011239985.1XP_011238287.1  

    See identical proteins and their annotated locations for XP_011238287.1

    Conserved Domains (1) summary
    cd01319
    Location:238745
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
  4. XM_006500870.2XP_006500933.1  

    See identical proteins and their annotated locations for XP_006500933.1

    Conserved Domains (1) summary
    cd01319
    Location:238745
    AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    110407636..110420242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)