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ACOT2 acyl-CoA thioesterase 2 [ Homo sapiens (human) ]

Gene ID: 10965, updated on 8-May-2016
Official Symbol
ACOT2provided by HGNC
Official Full Name
acyl-CoA thioesterase 2provided by HGNC
Primary source
HGNC:HGNC:18431
See related
Ensembl:ENSG00000119673 HPRD:10173; MIM:609972; Vega:OTTHUMG00000171608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128
Summary
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Orthologs
Location:
14q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (73567620..73575658)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74034324..74042362)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 4 Neighboring gene chromosome 14 open reading frame 169 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 2 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 1 Neighboring gene transfer RNA-Lys (TTT) 14-1 Neighboring gene acyl-CoA thioesterase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
 
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
acyl-coenzyme A thioesterase 2, mitochondrial
Names
acyl-coenzyme A thioester hydrolase 2a
long-chain acyl-CoA thioesterase 2
mitochondrial acyl-CoA thioesterase 1
peroxisomal long-chain acyl-coA thioesterase 2
NP_006812.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006821.5NP_006812.3  acyl-coenzyme A thioesterase 2, mitochondrial

    See identical proteins and their annotated locations for NP_006812.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AI537078, AK001939, BC006335, L40401
    Consensus CDS
    CCDS9816.1
    UniProtKB/Swiss-Prot
    P49753
    Related
    ENSP00000238651, OTTHUMP00000246591, ENST00000238651, OTTHUMT00000414435
    Conserved Domains (3) summary
    pfam01738
    Location:206468
    DLH; Dienelactone hydrolase family
    pfam04775
    Location:77204
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:266474
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

RNA

  1. NR_046028.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005225, AI537078, AK093131
    Related
    ENST00000538782, OTTHUMT00000414434

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    73567620..73575658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720007.1XP_006720070.1  

    See identical proteins and their annotated locations for XP_006720070.1

    UniProtKB/TrEMBL
    B3KSA0
    Conserved Domains (1) summary
    pfam08840
    Location:69277
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    73973914..73981955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)