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MLLT11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [ Homo sapiens (human) ]

Gene ID: 10962, updated on 8-May-2016
Official Symbol
MLLT11provided by HGNC
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11provided by HGNC
Primary source
HGNC:HGNC:16997
See related
Ensembl:ENSG00000213190 HPRD:05251; MIM:604684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF1Q
Summary
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1q21
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (151059675..151068497)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151032151..151040973)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene chromosome 1 open reading frame 56 Neighboring gene CDC42 small effector 1 Neighboring gene GA binding protein transcription factor beta subunit 2 Neighboring gene semaphorin 6C

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein AF1q
Names
ALL1 fused gene from chromosome 1q
ALL1-fused gene from chromosome 1q
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006818.3NP_006809.1  protein AF1q

    See identical proteins and their annotated locations for NP_006809.1

    Status: REVIEWED

    Source sequence(s)
    BC006471, BC022448
    Consensus CDS
    CCDS982.1
    UniProtKB/Swiss-Prot
    Q13015
    UniProtKB/TrEMBL
    Q6FGF7
    Related
    ENSP00000357917, OTTHUMP00000033120, ENST00000368921, OTTHUMT00000085103
    Conserved Domains (1) summary
    pfam15017
    Location:328
    AF1Q; Drug resistance and apoptosis regulator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    151059675..151068497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    152427468..152436290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)