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NOX4 NADPH oxidase 4 [ Bos indicus (zebu cattle) ]

Gene ID: 109554594, updated on 14-Mar-2024

Summary

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Gene symbol
NOX4
Gene description
NADPH oxidase 4
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos indicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 29
Exon count:
18
Annotation release Status Assembly Chr Location
100 current Bos_indicus_1.0 (GCF_000247795.1) 29 NC_032678.1 (6137124..6318470)

Chromosome 29 - NC_032678.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing protein 64-like Neighboring gene Putative N-acetylated-alpha-linked acidic dipeptidase Neighboring gene tyrosinase Neighboring gene glutamate metabotropic receptor 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032678.1 Chromosome 29 Reference Bos_indicus_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NADPH oxidase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos indicus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_indicus_1.0 Primary Assembly

Genomic

  1. NC_032678.1 Reference Bos_indicus_1.0 Primary Assembly

    Range
    6137124..6318470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019955214.1 → XP_019810773.1  NADPH oxidase 4 isoform X1

    UniProtKB/TrEMBL
    A0A6P5AVL2
    Conserved Domains (2) summary
    cd06186
    Location:263 → 529
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cl26813
    Location:21 → 452
    PLN02844; oxidoreductase/ferric-chelate reductase

  2. XM_019955215.1 → XP_019810774.1  NADPH oxidase 4 isoform X2

    UniProtKB/TrEMBL
    A0A6P5BKN7
    Conserved Domains (2) summary
    cd06186
    Location:237 → 503
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:5 → 130
    Ferric_reduct; Ferric reductase like transmembrane component
Nucleotide Protein
Heading Accession and Version

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