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kmt2d lysine (K)-specific methyltransferase 2D [ Hippocampus comes (tiger tail seahorse) ]

Gene ID: 109531346, updated on 14-Mar-2024

Summary

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Gene symbol
kmt2d
Gene description
lysine (K)-specific methyltransferase 2D
Gene type
protein coding
RefSeq status
MODEL
Organism
Hippocampus comes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Syngnathiaria; Syngnathiformes; Syngnathoidei; Syngnathidae; Hippocampus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
59
Annotation release Status Assembly Chr Location
100 current H_comes_QL1_v1 (GCF_001891065.1) Unplaced Scaffold NW_017806160.1 (428630..466953, complement)

NW_017806160.1Genomic Context describing neighboring genes Neighboring gene activin A receptor like type 1 Neighboring gene activin A receptor type 1Ba Neighboring gene uncharacterized LOC109531348 Neighboring gene desert hedgehog signaling molecule Neighboring gene limb development membrane protein 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_017806160.1 Unplaced Scaffold Reference H_comes_QL1_v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase 2D
Names
lysine methyltransferase 2D

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Hippocampus comes Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference H_comes_QL1_v1 Primary Assembly

Genomic

  1. NW_017806160.1 Reference H_comes_QL1_v1 Primary Assembly

    Range
    428630..466953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019895605.1 → XP_019751164.1  histone-lysine N-methyltransferase 2D isoform X5

    Conserved Domains (17) summary
    smart00398
    Location:1459 → 1514
    HMG; high mobility group
    smart00249
    Location:342 → 382
    PHD; PHD zinc finger
    smart00317
    Location:4805 → 4927
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4929 → 4945
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:331 → 346
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:215 → 259
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:871 → 917
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15595
    Location:261 → 306
    PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15597
    Location:820 → 870
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:948 → 998
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4589 → 4640
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4646 → 4730
    FYRC; F/Y rich C-terminus
    pfam09606
    Location:3424 → 3680
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:4440 → 4546
    PHD_SF; PHD finger superfamily
    cl25716
    Location:2632 → 2722
    Amelogenin
    cl25764
    Location:2984 → 3150
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:1729 → 2392
    Atrophin-1; Atrophin-1 family

  2. XM_019895604.1 → XP_019751163.1  histone-lysine N-methyltransferase 2D isoform X4

    Conserved Domains (17) summary
    smart00398
    Location:1466 → 1521
    HMG; high mobility group
    smart00249
    Location:342 → 382
    PHD; PHD zinc finger
    smart00317
    Location:4811 → 4933
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4935 → 4951
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:331 → 346
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:215 → 259
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:878 → 924
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15595
    Location:261 → 306
    PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15597
    Location:827 → 877
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:955 → 1005
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4595 → 4646
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4652 → 4736
    FYRC; F/Y rich C-terminus
    pfam09606
    Location:3430 → 3686
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:4446 → 4552
    PHD_SF; PHD finger superfamily
    cl25716
    Location:2638 → 2728
    Amelogenin
    cl25764
    Location:2990 → 3156
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:1735 → 2398
    Atrophin-1; Atrophin-1 family

  3. XM_019895600.1 → XP_019751159.1  histone-lysine N-methyltransferase 2D isoform X1

    Conserved Domains (17) summary
    smart00398
    Location:1466 → 1521
    HMG; high mobility group
    smart00249
    Location:342 → 382
    PHD; PHD zinc finger
    smart00317
    Location:4812 → 4934
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4936 → 4952
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:331 → 346
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:215 → 259
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:878 → 924
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15595
    Location:261 → 306
    PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15597
    Location:827 → 877
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:955 → 1005
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4596 → 4647
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4653 → 4737
    FYRC; F/Y rich C-terminus
    pfam09606
    Location:3431 → 3687
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:4447 → 4553
    PHD_SF; PHD finger superfamily
    cl25716
    Location:2639 → 2729
    Amelogenin
    cl25764
    Location:2991 → 3157
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:1736 → 2399
    Atrophin-1; Atrophin-1 family

  4. XM_019895601.1 → XP_019751160.1  histone-lysine N-methyltransferase 2D isoform X2

    Conserved Domains (17) summary
    smart00398
    Location:1466 → 1521
    HMG; high mobility group
    smart00249
    Location:342 → 382
    PHD; PHD zinc finger
    smart00317
    Location:4812 → 4934
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4936 → 4952
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:331 → 346
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:215 → 259
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:878 → 924
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15595
    Location:261 → 306
    PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15597
    Location:827 → 877
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:955 → 1005
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4596 → 4647
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4653 → 4737
    FYRC; F/Y rich C-terminus
    pfam09606
    Location:3431 → 3687
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:4447 → 4553
    PHD_SF; PHD finger superfamily
    cl25716
    Location:2639 → 2729
    Amelogenin
    cl25764
    Location:2991 → 3157
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:1736 → 2399
    Atrophin-1; Atrophin-1 family

  5. XM_019895603.1 → XP_019751162.1  histone-lysine N-methyltransferase 2D isoform X3

    Conserved Domains (17) summary
    smart00398
    Location:1466 → 1521
    HMG; high mobility group
    smart00249
    Location:342 → 382
    PHD; PHD zinc finger
    smart00317
    Location:4812 → 4934
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4936 → 4952
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:331 → 346
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:215 → 259
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:878 → 924
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15595
    Location:261 → 306
    PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15597
    Location:827 → 877
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:955 → 1005
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4596 → 4647
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:4653 → 4737
    FYRC; F/Y rich C-terminus
    pfam09606
    Location:3431 → 3687
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:4447 → 4553
    PHD_SF; PHD finger superfamily
    cl25716
    Location:2639 → 2729
    Amelogenin
    cl25764
    Location:2991 → 3157
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:1736 → 2399
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
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