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SRSF8 serine/arginine-rich splicing factor 8 [ Homo sapiens (human) ]

Gene ID: 10929, updated on 26-May-2016
Official Symbol
SRSF8provided by HGNC
Official Full Name
serine/arginine-rich splicing factor 8provided by HGNC
Primary source
HGNC:HGNC:16988
See related
Ensembl:ENSG00000263465 HPRD:04466; MIM:603269; Vega:OTTHUMG00000188534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSM-1; SRP46; SFRS2B
Summary
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Orthologs
Location:
11q22
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (95066877..95071227)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94800041..94804387)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4E pseudogene Neighboring gene lysine demethylase 4D pseudogene Neighboring gene endonuclease domain containing 1 Neighboring gene BUD13 homolog pseudogene 1

Protein interactions

Protein Gene Interaction Pubs
Tat tat Serine/arginine-rich splicing factor 8 (SRSF8) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

Go to the HIV-1, Human Interaction Database

  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ99817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/arginine-rich splicing factor 8
Names
SR splicing factor 8
pre-mRNA-splicing factor SRP46
splicing factor, arginine/serine-rich 2B
splicing factor, arginine/serine-rich, 46kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032102.3NP_115285.1  serine/arginine-rich splicing factor 8

    See identical proteins and their annotated locations for NP_115285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AF031166, AK023379, AP001264, BC057783, DA723253, KF510392
    Consensus CDS
    CCDS73370.1
    UniProtKB/Swiss-Prot
    Q9BRL6
    UniProtKB/TrEMBL
    A0A024R3A8
    Related
    ENSP00000480140, OTTHUMP00000276804, ENST00000587424, OTTHUMT00000477545
    Conserved Domains (2) summary
    smart00360
    Location:1587
    RRM; RNA recognition motif
    cd12311
    Location:1688
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RNA

  1. NR_103726.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF031166, AK023379, AP001264, BC057783, DA723253, KF510392

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    95066877..95071227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_428967.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    94683038..94687389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)