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ERBB3 erb-b2 receptor tyrosine kinase 3 [ Panthera pardus (leopard) ]

Gene ID: 109270315, updated on 11-Apr-2024

Summary

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Gene symbol
ERBB3
Gene description
erb-b2 receptor tyrosine kinase 3
See related
Ensembl:ENSPPRG00000002346
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera pardus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_02 current ASM2436296v1 (GCF_024362965.1) Unplaced Scaffold NW_026526991.1 (59047770..59065602, complement)
100 previous assembly PanPar1.0 (GCF_001857705.1) Unplaced Scaffold NW_017619872.1 (1189643..1209394)

NW_026526991.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC128775056 Neighboring gene proliferation-associated 2G4 Neighboring gene INO80 complex subunit C-like Neighboring gene ribosomal protein S26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neuregulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neuregulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_024362965.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM2436296v1 Primary Assembly

Genomic

  1. NW_026526991.1 Reference ASM2436296v1 Primary Assembly

    Range
    59047770..59065602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019454740.2 → XP_019310285.1  receptor tyrosine-protein kinase erbB-3

    UniProtKB/TrEMBL
    A0A9V1FVZ1
    Related
    ENSPPRP00000007033.1
    Conserved Domains (5) summary
    cd05111
    Location:701 → 979
    PTK_HER3; Pseudokinase domain of the Protein Tyrosine Kinase, HER3
    cd12095
    Location:638 → 676
    TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
    pfam00757
    Location:183 → 329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:56 → 167
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:499 → 630
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein
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