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TCERG1 transcription elongation regulator 1 [ Homo sapiens (human) ]

Gene ID: 10915, updated on 7-Aug-2014
Official Symbol
TCERG1provided by HGNC
Official Full Name
transcription elongation regulator 1provided by HGNC
Primary source
HGNC:15630
See related
Ensembl:ENSG00000113649; HPRD:10393; MIM:605409; Vega:OTTHUMG00000129683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Urn1; CA150; TAF2S
Summary
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
See TCERG1 in Epigenomics, MapViewer
Location:
5q31
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (146447310..146511508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145826873..145891071)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 27 Neighboring gene POU class 4 homeobox 3 Neighboring gene G protein-coupled receptor 151 Neighboring gene RNA, 5S ribosomal pseudogene 196

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-mediated splicing is dependent on splicing associated factors Tat-SF1 and CA150 PubMed
tat Both CA150 and HIV-1 Tat associate with the RNA polymerase II holoenzyme and are required for Tat transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133200

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
 
RNA polymerase II transcription corepressor activity IDA
Inferred from Direct Assay
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
proline-rich region binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transcription elongation regulator 1
Names
transcription elongation regulator 1
co-activator of 150 kDa
transcription factor CA150
TATA box-binding protein-associated factor 2S
TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040006.1NP_001035095.1  transcription elongation regulator 1 isoform 2

    See proteins identical to NP_001035095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AB209910, AF017789, DA034307, DA737038
    Consensus CDS
    CCDS43379.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000377943, OTTHUMP00000223941, ENST00000394421, OTTHUMT00000373450
    Conserved Domains (5) summary
    smart00441
    Location:934989
    Blast Score: 136
    FF; Contains two conserved F residues
    cd00201
    Location:412439
    Blast Score: 121
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:773822
    Blast Score: 163
    FF; FF domain
    pfam07777
    Location:300423
    Blast Score: 130
    MFMR; G-box binding protein MFMR
    pfam14931
    Location:819882
    Blast Score: 85
    IFT20; Intraflagellar transport complex B, subunit 20
  2. NM_006706.3NP_006697.2  transcription elongation regulator 1 isoform 1

    See proteins identical to NP_006697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF017789, BC111727, DA034307, DA737038
    Consensus CDS
    CCDS4282.1
    UniProtKB/Swiss-Prot
    O14776
    Related
    ENSP00000296702, OTTHUMP00000160091, ENST00000296702, OTTHUMT00000251886
    Conserved Domains (5) summary
    smart00441
    Location:9551010
    Blast Score: 137
    FF; Contains two conserved F residues
    cd00201
    Location:433460
    Blast Score: 122
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:794843
    Blast Score: 164
    FF; FF domain
    pfam07777
    Location:300444
    Blast Score: 110
    MFMR; G-box binding protein MFMR
    pfam14931
    Location:840903
    Blast Score: 86
    IFT20; Intraflagellar transport complex B, subunit 20

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    146447310..146511508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268365.1XP_005268422.1  

    Conserved Domains (5) summary
    smart00441
    Location:9721027
    Blast Score: 138
    FF; Contains two conserved F residues
    cd00201
    Location:433460
    Blast Score: 122
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:811860
    Blast Score: 165
    FF; FF domain
    pfam07777
    Location:300444
    Blast Score: 111
    MFMR; G-box binding protein MFMR
    pfam14931
    Location:857920
    Blast Score: 86
    IFT20; Intraflagellar transport complex B, subunit 20
  2. XM_005268367.1XP_005268424.1  

    Conserved Domains (4) summary
    smart00441
    Location:911966
    Blast Score: 141
    FF; Contains two conserved F residues
    cd00201
    Location:433460
    Blast Score: 121
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:811860
    Blast Score: 168
    FF; FF domain
    pfam07777
    Location:300444
    Blast Score: 107
    MFMR; G-box binding protein MFMR
  3. XM_005268366.1XP_005268423.1  

    Conserved Domains (5) summary
    smart00441
    Location:9511006
    Blast Score: 137
    FF; Contains two conserved F residues
    cd00201
    Location:412439
    Blast Score: 121
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:790839
    Blast Score: 163
    FF; FF domain
    pfam07777
    Location:300423
    Blast Score: 131
    MFMR; G-box binding protein MFMR
    pfam14931
    Location:836899
    Blast Score: 86
    IFT20; Intraflagellar transport complex B, subunit 20
  4. XM_006714754.1XP_006714817.1  

    Conserved Domains (3) summary
    cd00201
    Location:433460
    Blast Score: 121
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:744793
    Blast Score: 171
    FF; FF domain
    pfam07777
    Location:300444
    Blast Score: 92
    MFMR; G-box binding protein MFMR

RNA

  1. XR_245850.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    140973807..141037975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    145259570..145323747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)