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UTS2 urotensin 2 [ Homo sapiens (human) ]

Gene ID: 10911, updated on 8-May-2016
Official Symbol
UTS2provided by HGNC
Official Full Name
urotensin 2provided by HGNC
Primary source
HGNC:HGNC:12636
See related
Ensembl:ENSG00000049247 HPRD:04976; MIM:604097; Vega:OTTHUMG00000001218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UII; U-II; UCN2; PRO1068
Summary
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p36
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (7847612..7913610, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (7907672..7913551, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376693 Neighboring gene vesicle associated membrane protein 3 Neighboring gene period circadian clock 3 Neighboring gene tumor necrosis factor receptor superfamily member 9 Neighboring gene Parkinsonism associated deglycase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glomerular filtration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of urine volume IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of circadian sleep/wake cycle, REM sleep IEA
Inferred from Electronic Annotation
more info
 
positive regulation of circadian sleep/wake cycle, wakefulness IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasodilation IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
urotensin-2
Names
prepro U-II
urotensin II

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006786.3NP_006777.1  urotensin-2 isoform b preproprotein

    See identical proteins and their annotated locations for NP_006777.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes a shorter preproprotein isoform (b) of 124 amino acids with a different amino-terminal end compared to isoform a. The mature peptide is identical for both transcript variants.
    Source sequence(s)
    AF104118, AY358375
    Consensus CDS
    CCDS91.1
    UniProtKB/Swiss-Prot
    O95399
    Related
    ENSP00000355163, OTTHUMP00000001357, ENST00000361696, OTTHUMT00000003612
    Conserved Domains (1) summary
    pfam02083
    Location:113124
    Urotensin_II; Urotensin II
  2. NM_021995.2NP_068835.1  urotensin-2 isoform a preproprotein

    See identical proteins and their annotated locations for NP_068835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a longer preproprotein isoform (a) of 139 amino acids with a different amino-terminal end compared to isoform b. The mature peptide is identical for both transcript variants.
    Source sequence(s)
    AF140630, AY358375, BC126443
    Consensus CDS
    CCDS90.1
    UniProtKB/Swiss-Prot
    O95399
    UniProtKB/TrEMBL
    A0AVP6
    Related
    ENSP00000054668, OTTHUMP00000001358, ENST00000054668, OTTHUMT00000003613
    Conserved Domains (1) summary
    pfam02083
    Location:128139
    Urotensin_II; Urotensin II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    7847612..7913610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540537.1XP_011538839.1  

    See identical proteins and their annotated locations for XP_011538839.1

    UniProtKB/Swiss-Prot
    O95399
    Conserved Domains (1) summary
    pfam02083
    Location:128139
    Urotensin_II; Urotensin II
  2. XM_011540538.1XP_011538840.1  

    See identical proteins and their annotated locations for XP_011538840.1

    UniProtKB/Swiss-Prot
    O95399
    Conserved Domains (1) summary
    pfam02083
    Location:113124
    Urotensin_II; Urotensin II

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    7895413..7901298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)