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Tpr translocated promoter region, nuclear basket protein [ Mus musculus (house mouse) ]

Gene ID: 108989, updated on 28-May-2016
Official Symbol
Tprprovided by MGI
Official Full Name
translocated promoter region, nuclear basket proteinprovided by MGI
Primary source
MGI:MGI:1922066
See related
Ensembl:ENSMUSG00000006005 Vega:OTTMUSG00000029496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C77892; 2610029M07Rik
Orthologs
Location:
1; 1 G1
Exon count:
52
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (150392838..150449935)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (152239968..152297065)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15453 Neighboring gene RIKEN cDNA 2310030A07 gene Neighboring gene phosducin Neighboring gene cDNA sequence BC003331 Neighboring gene proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Neighboring gene predicted gene, 41967 Neighboring gene spindle and kinetochore associated complex subunit 2-like, pseudogene

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
nucleocytoplasmic transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleocytoplasmic transporter activity ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK import into nucleus ISO
Inferred from Sequence Orthology
more info
 
RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
RNA import into nucleus ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus in response to heat stress ISO
Inferred from Sequence Orthology
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
mitotic spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
negative regulation of RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of heterochromatin assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic sister chromatid separation ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
nuclear periphery ISO
Inferred from Sequence Orthology
more info
 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore ISO
Inferred from Sequence Orthology
more info
 
nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nucleoprotein TPR
Names
NPC-associated intranuclear protein
nuclear pore complex-associated protein Tpr
translocated promoter region and nuclear basket protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133780.3NP_598541.3  nucleoprotein TPR

    See identical proteins and their annotated locations for NP_598541.3

    Status: VALIDATED

    Source sequence(s)
    AC161432
    Consensus CDS
    CCDS35734.2
    UniProtKB/Swiss-Prot
    F6ZDS4
    Related
    ENSMUSP00000117616, OTTMUSP00000037868, ENSMUST00000124973, OTTMUST00000073201
    Conserved Domains (5) summary
    pfam05483
    Location:3631147
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam07926
    Location:11101241
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam14915
    Location:13941664
    CCDC144C; CCDC144C protein coiled-coil region
    cl12013
    Location:300446
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19219
    Location:430595
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    150392838..150449935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529065.1XP_006529128.1  

    Conserved Domains (5) summary
    pfam05483
    Location:3631145
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam07926
    Location:11081239
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam14915
    Location:13921662
    CCDC144C; CCDC144C protein coiled-coil region
    cl12013
    Location:300446
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19219
    Location:430595
    DUF342; Protein of unknown function (DUF342)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    152832018..152889087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)