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LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens (human) ]

Gene ID: 10894, updated on 4-May-2015
Official Symbol
LYVE1provided by HGNC
Official Full Name
lymphatic vessel endothelial hyaluronan receptor 1provided by HGNC
Primary source
HGNC:HGNC:14687
See related
HPRD:05753; MIM:605702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAR; XLKD1; LYVE-1; CRSBP-1
Summary
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
Orthologs
See LYVE1 in MapViewer
Location:
11p15
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (10557866..10568818, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10578712..10590365, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MT-RNR2-like 8 Neighboring gene microRNA 4485 Neighboring gene ring finger protein 141 Neighboring gene MRVI1 antisense RNA 1 Neighboring gene murine retrovirus integration site 1 homolog Neighboring gene CTR9, Paf1/RNA polymerase II complex component

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Hyaluronan metabolism, organism-specific biosystem (from REACTOME)
    Hyaluronan metabolism, organism-specific biosystemHyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular m...
  • Hyaluronan uptake and degradation, organism-specific biosystem (from REACTOME)
    Hyaluronan uptake and degradation, organism-specific biosystemHyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by th...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
 
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
glycosaminoglycan metabolic process TAS
Traceable Author Statement
more info
 
hyaluronan catabolic process TAS
Traceable Author Statement
more info
 
hyaluronan metabolic process TAS
Traceable Author Statement
more info
 
movement of cell or subcellular component TAS
Traceable Author Statement
more info
PubMed 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
lymphatic vessel endothelial hyaluronic acid receptor 1
Names
lymphatic vessel endothelial hyaluronic acid receptor 1
cell surface retention sequence binding protein-1
cell surface retention sequence-binding protein 1
extracellular link domain containing 1
extracellular link domain-containing 1
extracellular link domain-containing protein 1
hyaluronic acid receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006691.3NP_006682.2  lymphatic vessel endothelial hyaluronic acid receptor 1 precursor

    See identical proteins and their annotated locations for NP_006682.2

    Status: REVIEWED

    Source sequence(s)
    AY358925, CA449932, DA924658
    Consensus CDS
    CCDS7804.1
    UniProtKB/TrEMBL
    B2R672
    UniProtKB/Swiss-Prot
    Q9Y5Y7
    Conserved Domains (1) summary
    cd03516
    Location:34174
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    10557866..10568818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    10577487..10589311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)