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wrn WRN RecQ like helicase [ Scleropages formosus (Asian bonytongue) ]

Gene ID: 108929909, updated on 14-Mar-2024

Summary

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Gene symbol
wrn
Gene description
WRN RecQ like helicase
See related
Ensembl:ENSSFOG00015006123
Gene type
protein coding
RefSeq status
MODEL
Organism
Scleropages formosus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 6
Exon count:
38
Annotation release Status Assembly Chr Location
101 current fSclFor1.1 (GCF_900964775.1) 6 NC_041811.1 (15107003..15140538, complement)
100 previous assembly ASM162426v1 (GCF_001624265.1) Unplaced Scaffold NW_017371627.1 (1000655..1033933)

Chromosome 6 - NC_041811.1Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 10 Neighboring gene neuregulin 1 Neighboring gene purine-rich element binding protein G Neighboring gene testis expressed 15, meiosis and synapsis associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in G-quadruplex DNA unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Werner syndrome ATP-dependent helicase
Names
Werner syndrome RecQ like helicase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Scleropages formosus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fSclFor1.1 Primary Assembly

Genomic

  1. NC_041811.1 Reference fSclFor1.1 Primary Assembly

    Range
    15107003..15140538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018744763.2 → XP_018600279.2  Werner syndrome ATP-dependent helicase isoform X3

    UniProtKB/TrEMBL
    A0A8C9R2H8
    Conserved Domains (4) summary
    TIGR00614
    Location:478 → 951
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06141
    Location:57 → 225
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam00570
    Location:1082 → 1148
    HRDC; HRDC domain
    pfam14493
    Location:1185 → 1277
    HTH_40; Helix-turn-helix domain

  2. XM_018744761.2 → XP_018600277.2  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8C9R2H8, A0A8C9RCP7
    Related
    ENSSFOP00015009427.2, ENSSFOT00015009555.2
    Conserved Domains (4) summary
    TIGR00614
    Location:478 → 951
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06141
    Location:57 → 225
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam00570
    Location:1082 → 1148
    HRDC; HRDC domain
    pfam14493
    Location:1185 → 1277
    HTH_40; Helix-turn-helix domain

  3. XM_018744762.2 → XP_018600278.2  Werner syndrome ATP-dependent helicase isoform X2

    UniProtKB/TrEMBL
    A0A8C9R2H8, A0A8C9R5A6
    Related
    ENSSFOP00015009458.2, ENSSFOT00015009587.2
    Conserved Domains (4) summary
    TIGR00614
    Location:478 → 951
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06141
    Location:57 → 225
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam00570
    Location:1082 → 1148
    HRDC; HRDC domain
    pfam14493
    Location:1185 → 1277
    HTH_40; Helix-turn-helix domain

  4. XM_018744760.2 → XP_018600276.2  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8C9R2H8, A0A8C9RCP7
    Conserved Domains (4) summary
    TIGR00614
    Location:478 → 951
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06141
    Location:57 → 225
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam00570
    Location:1082 → 1148
    HRDC; HRDC domain
    pfam14493
    Location:1185 → 1277
    HTH_40; Helix-turn-helix domain

  5. XM_018744765.2 → XP_018600281.2  Werner syndrome ATP-dependent helicase isoform X4

    UniProtKB/TrEMBL
    A0A8C9R2H8
    Conserved Domains (4) summary
    TIGR00614
    Location:315 → 788
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    pfam00570
    Location:919 → 985
    HRDC; HRDC domain
    pfam14493
    Location:1022 → 1114
    HTH_40; Helix-turn-helix domain
    cl10012
    Location:2 → 62
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
Nucleotide Protein
Heading Accession and Version

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