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PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [ Homo sapiens (human) ]

Gene ID: 10891, updated on 26-Jul-2015
Official Symbol
PPARGC1Aprovided by HGNC
Official Full Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:9237
See related
Ensembl:ENSG00000109819; HPRD:05155; MIM:604517; Vega:OTTHUMG00000097747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)
Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Orthologs
See PPARGC1A in Epigenomics, MapViewer
Location:
4p15.1
Exon count:
24
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (23792021..24472771, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (23793644..24474394, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374527 Neighboring gene uncharacterized LOC105374526 Neighboring gene uncharacterized LOC105374529 Neighboring gene microRNA 573 Neighboring gene DEAH (Asp-Glu-Ala-His) box helicase 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    ATF-2 transcription factor network, organism-specific biosystem
    ATF-2 transcription factor network
  • Activation of PPARGC1A (PGC-1alpha) by phosphorylation, organism-specific biosystem (from REACTOME)
    Activation of PPARGC1A (PGC-1alpha) by phosphorylation, organism-specific biosystemThe transcriptional coactivator PPARGC1A (PGC-1alpha), one of the master regulators of mitochondrial biogenesis, is activated by phosphorylation. Energy depletion causes a reduction in ATP and an inc...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Energy Metabolism, organism-specific biosystem (from WikiPathways)
    Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Mitochondrial Gene Expression, organism-specific biosystem (from WikiPathways)
    Mitochondrial Gene Expression, organism-specific biosystemNumerous nuclear-encoded genes co-ordinate the expression of genes encoded on the mitochondrial genome.
  • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • RORA activates gene expression, organism-specific biosystem (from REACTOME)
    RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
    SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders N??r.
  • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class III, organism-specific biosystem
    Signaling events mediated by HDAC Class III
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
  • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
  • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II transcription cofactor activity TAS
Traceable Author Statement
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ligand-dependent nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligand-dependent nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
brown fat cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cellular glucose homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
cellular respiration TAS
Traceable Author Statement
more info
PubMed 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitrite IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to thyroid hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm TAS
Traceable Author Statement
more info
 
digestion TAS
Traceable Author Statement
more info
PubMed 
fatty acid oxidation NAS
Non-traceable Author Statement
more info
PubMed 
flavone metabolic process IEA
Inferred from Electronic Annotation
more info
 
galactose metabolic process IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis NAS
Non-traceable Author Statement
more info
PubMed 
mRNA processing TAS
Traceable Author Statement
more info
PubMed 
mitochondrion organization NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion organization TAS
Traceable Author Statement
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of receptor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
organelle organization TAS
Traceable Author Statement
more info
 
positive regulation of ATP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular respiration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fatty acid oxidation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of gluconeogenesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of histone acetylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mitochondrial DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
protein complex assembly TAS
Traceable Author Statement
more info
PubMed 
protein stabilization TAS
Traceable Author Statement
more info
PubMed 
regulation of N-methyl-D-aspartate selective glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
respiratory electron transport chain ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
response to epinephrine IEA
Inferred from Electronic Annotation
more info
 
response to leucine IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity ISS
Inferred from Sequence or Structural Similarity
more info
 
response to norepinephrine IEA
Inferred from Electronic Annotation
more info
 
response to starvation NAS
Non-traceable Author Statement
more info
PubMed 
response to statin IEA
Inferred from Electronic Annotation
more info
 
temperature homeostasis TAS
Traceable Author Statement
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
DNA-directed RNA polymerase II, core complex TAS
Traceable Author Statement
more info
PubMed 
PML body IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Names
L-PGC-1alpha
PGC-1-alpha
PPAR gamma coactivator variant form
PPARGC-1-alpha
ligand effect modulator-6
peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4
peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext
peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a
peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5
peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028250.1 RefSeqGene

    Range
    5001..103057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013261.3NP_037393.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha

    See identical proteins and their annotated locations for NP_037393.1

    Status: REVIEWED

    Source sequence(s)
    AC092834, AF106698, AF186379
    Consensus CDS
    CCDS3429.1
    UniProtKB/TrEMBL
    A0A024R9Q9
    UniProtKB/Swiss-Prot
    Q9UBK2
    Related
    ENSP00000264867, OTTHUMP00000123372, ENST00000264867, OTTHUMT00000214976
    Conserved Domains (3) summary
    PHA03420
    Location:200295
    PHA03420; E4 protein; Provisional
    cd12623
    Location:675765
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:679739
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    23792021..24472771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248130.2XP_005248187.1  

    See identical proteins and their annotated locations for XP_005248187.1

    UniProtKB/Swiss-Prot
    Q9UBK2
    Conserved Domains (3) summary
    PHA03420
    Location:205300
    PHA03420; E4 protein; Provisional
    cd12623
    Location:680770
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:684744
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  2. XM_011513765.1XP_011512067.1  

    See identical proteins and their annotated locations for XP_011512067.1

    UniProtKB/Swiss-Prot
    Q9UBK2
    Conserved Domains (3) summary
    PHA03420
    Location:188283
    PHA03420; E4 protein; Provisional
    cd12623
    Location:663753
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:667727
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  3. XM_005248134.3XP_005248191.1  

  4. XM_005248132.1XP_005248189.1  

    Conserved Domains (3) summary
    PHA03420
    Location:197292
    PHA03420; E4 protein; Provisional
    cd12623
    Location:672762
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:676736
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  5. XM_011513766.1XP_011512068.1  

    See identical proteins and their annotated locations for XP_011512068.1

    Conserved Domains (2) summary
    cd12623
    Location:640730
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:644704
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  6. XM_005248131.3XP_005248188.1  

    Conserved Domains (3) summary
    PHA03420
    Location:204299
    PHA03420; E4 protein; Provisional
    cd12623
    Location:679769
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:683743
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  7. XM_011513764.1XP_011512066.1  

    Conserved Domains (3) summary
    PHA03420
    Location:200295
    PHA03420; E4 protein; Provisional
    cd12623
    Location:675765
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:679739
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  8. XM_011513768.1XP_011512070.1  

    See identical proteins and their annotated locations for XP_011512070.1

    Conserved Domains (2) summary
    cd12623
    Location:640730
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:644704
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  9. XM_011513767.1XP_011512069.1  

    See identical proteins and their annotated locations for XP_011512069.1

    Conserved Domains (2) summary
    cd12623
    Location:640730
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
    pfam14259
    Location:644704
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
  10. XM_011513771.1XP_011512073.1  

    See identical proteins and their annotated locations for XP_011512073.1

    UniProtKB/Swiss-Prot
    Q9UBK2
    Conserved Domains (3) summary
    PHA03420
    Location:73168
    PHA03420; E4 protein; Provisional
    pfam14259
    Location:552612
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
    cl17169
    Location:548638
    RRM_SF; RNA recognition motif (RRM) superfamily
  11. XM_011513770.1XP_011512072.1  

    See identical proteins and their annotated locations for XP_011512072.1

    UniProtKB/Swiss-Prot
    Q9UBK2
    Conserved Domains (3) summary
    PHA03420
    Location:73168
    PHA03420; E4 protein; Provisional
    pfam14259
    Location:552612
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)
    cl17169
    Location:548638
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. XM_011513769.1XP_011512071.1  

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    23791582..23889913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)