PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Homo sapiens (human)] - Gene

Summary

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Official Symbol: PPARGC1Aprovided by HGNC
Official Full Name: peroxisome proliferator-activated receptor gamma, coactivator 1 alphaprovided by HGNC
Primary source: HGNC:9237
See related: Ensembl:ENSG00000109819; HPRD:05155; MIM:604517; Vega:OTTHUMG00000097747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)
Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 4p15.1

Sequence :: Chromosome: 4; NC_000004.11 (23793644..23891700, complement)

See PPARGC1A in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results suggest that PGC-1a induction, which leads to elevated expression of gluconeogenetic genes and increased glucose production in hepatitis c virus (HCV)-infected cells, is a central mechanism of insulin resistance associated with HCV infection.
Title: The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance.
genetic association studies in a population of children in Taiwan: Data suggest that an SNP in PPARGC1A (rs8192678) is associated with nonalcoholic fatty liver disease in obese Taiwanese children.
Title: A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.
These data highlight the role of PGC1alpha-mediated mitochondrial biogenesis in neuroblatoma cells and suggest PGC1alpha as a potential target for enhancing the effectiveness of therapy in aggressive drug resistant neuroblastoma.
Title: Garlic-derived diallyl disulfide modulates peroxisome proliferator activated receptor gamma co-activator 1 alpha in neuroblastoma cells.
Inhibition of PGC-1a and PGC-1b blocks the alpha-MSH-mediated induction of MITF and melanogenic genes.
Title: PGC-1 coactivators regulate MITF and the tanning response.
Absence of PGC-1 proteins accelerated the transition to heart failure following pressure overload.
Title: PGC-1 proteins and heart failure.
TRbeta1 binds PGC-1alpha in a second ligand and LxxLL motif independent mode and show this interaction requires the TRbeta1 N-terminal domain and the PGC-1alpha N-terminal activation domain at amino acids 1-130.
Title: Distinct ligand-dependent and independent modes of thyroid hormone receptor (TR)/PGC-1α interaction.
findings suggest that PPARGC1A variations may influence PPARGC1A expression and the coordinating regulators of downstream targets in energy homeostasis
Title: An exonic peroxisome proliferator-activated receptor-γ coactivator-1α variation may mediate the resting energy expenditure through a potential regulatory role on important gene expression in this pathway.
Expression of PGC-1alpha4 is preferentially induced in mouse and human muscle during resistance exercise; these studies identify a PGC-1alpha protein that regulates and coordinates factors involved in skeletal muscle hypertrophy.
Title: A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.
overview of role of PPARGC1A in skeletal muscle: PPARGC1A appears to regulate mitochondrial biogenesis and expression of oxidoreductases. PPARGC1A appears to play protective role against atrophy-linked skeletal muscle deterioration. [REVIEW]
Title: Role of PGC-1α signaling in skeletal muscle health and disease.
FLCN deficiency and subsequent increased PPARGC1A expression result in increased mitochondrial function and oxidative metabolism as the source of cellular energy, which may drive hyperplastic transformation.
Title: Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.

Submit: New GeneRIF Correction See all (253)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_037393.1	NP_005113.1	NR1I3	BIND	PubMed	CAR interacts with PGC-1.
Q9UBK2	P03372	ESR1	HPRD	PubMed
Q9UBK2	Q92731	ESR2	HPRD	PubMed
Q9UBK2	P11474	ESRRA	HPRD	PubMed
Q9UBK2	P62508	ESRRG	HPRD	PubMed
Q9UBK2	P51610	HCFC1	HPRD	PubMed
Q9UBK2	P41235	HNF4A	HPRD	PubMed
Q9UBK2	Q16539	MAPK14	HPRD	PubMed
Q9UBK2	Q15648	MED1	HPRD	PubMed
Q9UBK2	Q9BQG0	MYBBP1A	HPRD	PubMed
Q9UBK2	P19338	NCL	HPRD	PubMed
Q9UBK2	Q15788	NCOA1	HPRD	PubMed
Q9UBK2	O75469	NR1I2	HPRD	PubMed
Q9UBK2	Q14994	NR1I3	HPRD	PubMed
Q9UBK2	P04150	NR3C1	HPRD	PubMed
Q9UBK2	Q16656	NRF1	HPRD	PubMed
Q9UBK2	Q07869	PPARA	HPRD	PubMed
Q9UBK2	P37231	PPARG	HPRD	PubMed
Q9UBK2	P19793	RXRA	HPRD	PubMed
Q9UBK2	Q96EB6	SIRT1	HPRD	PubMed
Q9UBK2	P37243	THRB	HPRD	PubMed
Q9UBK2	Q15853	USF2	HPRD	PubMed
BioGRID:116097	BioGRID:107076	BCL6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116097	BioGRID:107276	CAPNS1	BioGRID	PubMed	Two-hybrid
BioGRID:116097	BioGRID:107456	CDK6	BioGRID	PubMed	Biochemical Activity
BioGRID:116097	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:121817	CREBZF	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116097	BioGRID:108403	ESR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:116097	BioGRID:108404	ESR2	BioGRID	PubMed	Two-hybrid
BioGRID:116097	BioGRID:108405	ESRRA	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:116097	BioGRID:108407	ESRRG	BioGRID	PubMed	Reconstituted Complex
BioGRID:116097	BioGRID:204939	Esrrg	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex
BioGRID:116097	BioGRID:120581	FBXW7	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:109187	GSK3B	BioGRID	PubMed	Biochemical Activity
BioGRID:116097	BioGRID:109304	HCFC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:109414	HNF4A	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:116097	BioGRID:114353	IQGAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116097	BioGRID:115432	LRPPRC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:111465	MED1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:115293	MED12	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:114699	MED14	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:115342	MED16	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:114830	MED17	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:114862	MED20	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:114807	MED21	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:119124	MYEF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:110737	MYOD1	BioGRID	PubMed	Co-localization
BioGRID:116097	BioGRID:114200	NCOA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:116691	NCOA6	BioGRID	PubMed	Reconstituted Complex
BioGRID:116097	BioGRID:114380	NR1I2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:116097	BioGRID:109165	NR3C1	BioGRID	PubMed	Protein-peptide; Two-hybrid
BioGRID:116097	BioGRID:108772	NR5A2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:110955	NRF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:116446	PARK7	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:116097	BioGRID:114124	PIAS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:111461	PPARA	BioGRID	PubMed	Reconstituted Complex
BioGRID:116097	BioGRID:111464	PPARG	BioGRID	PubMed	Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:111972	RNF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:123169	RNF34	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:112168	RXRA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:116097	BioGRID:113368	SF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:112319	SFPQ	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:116983	SIRT1	BioGRID	PubMed	Co-localization
BioGRID:116097	BioGRID:112325	SRSF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:112327	SRSF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:112328	SRSF5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:112329	SRSF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116097	BioGRID:112924	THRB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:116097	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
ATF-2 transcription factor network, organism-specific biosystem
ATF-2 transcription factor network
Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem (from REACTOME)
BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK and BMAL1:NPAS2 heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz...
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 heterodimer transactivates CRY and PER genes by binding E-box element...
Circadian Repression of Expression by REV-ERBA, organism-specific biosystem (from REACTOME)
Circadian Repression of Expression by REV-ERBA, organism-specific biosystemREV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thu...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Energy Metabolism, organism-specific biosystem (from WikiPathways)
Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Insulin signaling pathway, organism-specific biosystem (from KEGG)
Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Insulin signaling pathway, conserved biosystem (from KEGG)
Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
Mitochondrial Gene Expression, organism-specific biosystem (from WikiPathways)
Mitochondrial Gene Expression, organism-specific biosystemNumerous nuclear-encoded genes co-ordinate the expression of genes encoded on the mitochondrial genome.
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
RORA Activates Circadian Expression, organism-specific biosystem (from REACTOME)
RORA Activates Circadian Expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders N??r.
Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by HDAC Class III, organism-specific biosystem
Signaling events mediated by HDAC Class III
Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
Signaling mediated by p38-alpha and p38-beta
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway

General gene information

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Markers

MARC_11849-11850:1029349088:1 (e-PCR)
- UniSTS:267275

RH93032 (e-PCR)
- UniSTS:88363

MARC_49176-49177:1118326844:1 (e-PCR)
- UniSTS:477493

PPARGC1A (e-PCR)
- UniSTS:503506

Ppargc1a (e-PCR), detects polymorphism
- UniSTS:479198

Genotypes

See PPARGC1A SNP Geneview Report
See PPARGC1A SNP Genotype Report
See PPARGC1A SNP Variation Viewer Report

Homology

Homologs of the PPARGC1A gene: The PPARGC1A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	ISS Inferred from Sequence or Structural Similarity more info
DNA binding	TAS Traceable Author Statement more info	PubMed
RNA binding	TAS Traceable Author Statement more info	PubMed
RNA polymerase II transcription cofactor activity	TAS Traceable Author Statement more info	PubMed
androgen receptor binding	NAS Non-traceable Author Statement more info	PubMed
chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
ligand-dependent nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
ligand-dependent nuclear receptor transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
RNA splicing	TAS Traceable Author Statement more info	PubMed
androgen receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
brown fat cell differentiation	TAS Traceable Author Statement more info	PubMed
cellular glucose homeostasis	NAS Non-traceable Author Statement more info	PubMed
cellular respiration	TAS Traceable Author Statement more info	PubMed
cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
digestion	TAS Traceable Author Statement more info	PubMed
fatty acid oxidation	NAS Non-traceable Author Statement more info	PubMed
gluconeogenesis	NAS Non-traceable Author Statement more info	PubMed
mRNA processing	TAS Traceable Author Statement more info	PubMed
mitochondrion organization	NAS Non-traceable Author Statement more info	PubMed
negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
neuron death	IDA Inferred from Direct Assay more info
positive regulation of ATP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of fatty acid oxidation	TAS Traceable Author Statement more info	PubMed
positive regulation of gluconeogenesis	TAS Traceable Author Statement more info	PubMed
positive regulation of histone acetylation	TAS Traceable Author Statement more info	PubMed
positive regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
protein complex assembly	TAS Traceable Author Statement more info	PubMed
protein stabilization	TAS Traceable Author Statement more info	PubMed
regulation of N-methyl-D-aspartate selective glutamate receptor activity	IEA Inferred from Electronic Annotation more info
regulation of cell death	IDA Inferred from Direct Assay more info
respiratory electron transport chain	ISS Inferred from Sequence or Structural Similarity more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to muscle activity	ISS Inferred from Sequence or Structural Similarity more info
response to starvation	NAS Non-traceable Author Statement more info	PubMed
temperature homeostasis	TAS Traceable Author Statement more info	PubMed
transcription initiation from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
DNA-directed RNA polymerase II, core complex	TAS Traceable Author Statement more info	PubMed
PML body	IEA Inferred from Electronic Annotation more info
cytosol	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Names: peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; L-PGC-1alpha; PPARGC-1-alpha; ligand effect modulator-6; PPAR gamma coactivator variant form; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028250.1 RefSeqGene

Range

5001..103057

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_013261.3 → NP_037393.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Status: REVIEWED

Source sequence(s)

AC092834, AF106698, AF186379

Consensus CDS

CCDS3429.1

UniProtKB/Swiss-Prot

Q9UBK2

Related

ENSP00000264867, OTTHUMP00000123372, ENST00000264867, OTTHUMT00000214976

Conserved Domains (1) summary

cd00590
Location:678 – 738
Blast Score: 137

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p10 Primary Assembly

Range

23793644..23891700, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

23138364..23236560, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018915.1 Alternate CHM1_1.0

Range

23733866..23832120, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01032676.1 (12799..78106)	None
genomic	ABBA01032677.1	None
genomic	AC092834.3	AAY41058.1
genomic	AF108205.1	AAF19083.1
genomic	AMYH01014061.1 (75661..95549)	None
genomic	AMYH01014062.1	None
genomic	AMYH01014063.1	None
genomic	CH471069.1	EAW92811.1
		EAW92812.1
genomic	EU280319.1	ABX44665.1
mRNA	AB061325.1	BAE46508.1
mRNA	AF106698.1	AAF18573.1
mRNA	AF159714.1	AAD51615.1
mRNA	AF186379.1	AAD56250.1
mRNA	AK024990.1	None
mRNA	AK296591.1	BAH12392.1
mRNA	AK301883.1	BAH13576.1
mRNA	AK309261.1	None
mRNA	BC029800.1	None
mRNA	HQ695733.1	ADW77180.1
mRNA	JQ772116.1	AFK29753.1
mRNA	JQ772117.1	AFK29754.1
mRNA	JQ772118.1	AFK29755.1
mRNA	JQ772119.1	AFK29756.1
mRNA	JQ772120.1	AFK29757.1
other-genetic	BC156323.1	AAI56324.1
other-genetic	BC157068.1	AAI57069.1