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Ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 108837, updated on 21-May-2016
Official Symbol
Ibtkprovided by MGI
Official Full Name
inhibitor of Bruton agammaglobulinemia tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1918677
See related
Ensembl:ENSMUSG00000035941 Vega:OTTMUSG00000045033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTKI; AA409502; mKIAA1417; 5430411K16Rik
Orthologs
Location:
9; 9 E3.1
Exon count:
29
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (85687359..85750435, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (85580963..85637766, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 pseudogene Neighboring gene family with sequence similarity 46, member A Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene ribosomal protein L7A pseudogene

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
inhibitor of Bruton tyrosine kinase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081282.2NP_001074751.1  inhibitor of Bruton tyrosine kinase

    See identical proteins and their annotated locations for NP_001074751.1

    Status: VALIDATED

    Source sequence(s)
    AK031796, BB639555, BC137798, BP760552
    Consensus CDS
    CCDS40712.1
    UniProtKB/Swiss-Prot
    Q6ZPR6
    Related
    ENSMUSP00000041145, OTTMUSP00000066062, ENSMUST00000039213, OTTMUST00000118333
    Conserved Domains (6) summary
    cd00204
    Location:47135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00415
    Location:247299
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:762872
    BTB; BTB/POZ domain
    pfam13540
    Location:232260
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    pfam13857
    Location:71125
    Ank_5; Ankyrin repeats (many copies)
    cd14821
    Location:872919
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    85687359..85750435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510765.2XP_006510828.1  

    Conserved Domains (6) summary
    cd00204
    Location:47135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00415
    Location:247299
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:761871
    BTB; BTB/POZ domain
    pfam13540
    Location:232260
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    pfam13857
    Location:71125
    Ank_5; Ankyrin repeats (many copies)
    cd14821
    Location:871918
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
  2. XM_006510766.2XP_006510829.1  

    Conserved Domains (2) summary
    pfam00651
    Location:202312
    BTB; BTB/POZ domain
    cd14821
    Location:312359
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    82775463..82837627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175371.2: Suppressed sequence

    Description
    NM_175371.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.