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ME3 malic enzyme 3 [ Homo sapiens (human) ]

Gene ID: 10873, updated on 26-May-2016
Official Symbol
ME3provided by HGNC
Official Full Name
malic enzyme 3provided by HGNC
Primary source
HGNC:HGNC:6985
See related
Ensembl:ENSG00000151376 HPRD:06862; MIM:604626; Vega:OTTHUMG00000167217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NADP-ME
Summary
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11cen-q22.3
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (86441108..86672636, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (86152150..86383678, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 81 Neighboring gene protein tyrosine phosphatase type IVA, member 1 pseudogene 6 Neighboring gene uncharacterized LOC105379410 Neighboring gene uncharacterized LOC102724775 Neighboring gene MOB family member 4, phocein pseudogene Neighboring gene protease, serine 23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ34862

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
cofactor binding TAS
Traceable Author Statement
more info
PubMed 
malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
malic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aerobic respiration TAS
Traceable Author Statement
more info
PubMed 
malate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxygen metabolic process TAS
Traceable Author Statement
more info
PubMed 
pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
NADP-dependent malic enzyme, mitochondrial
Names
malate dehydrogenase
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
malic enzyme 3, NADP(+)-dependent, mitochondrial
malic enzyme, NADP+-dependent, mitochondrial
mitochondrial NADP(+)-dependent malic enzyme 3
pyruvic-malic carboxylase
NP_001014811.1
NP_001155058.1
NP_006671.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014811.1NP_001014811.1  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_001014811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AA403046, AI198184, AI948779, AY424278, BC022472
    Consensus CDS
    CCDS8277.1
    UniProtKB/Swiss-Prot
    Q16798
    UniProtKB/TrEMBL
    Q6TCH8
    Related
    ENSP00000376998, OTTHUMP00000235498, ENST00000393324, OTTHUMT00000393767
    Conserved Domains (3) summary
    cd05312
    Location:305582
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:114295
    malic; Malic enzyme, N-terminal domain
  2. NM_001161586.1NP_001155058.1  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_001155058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AI560417, AK313695, BQ882896, CB306059, DC388623
    Consensus CDS
    CCDS8277.1
    UniProtKB/Swiss-Prot
    Q16798
    UniProtKB/TrEMBL
    B2R995
    Related
    ENSP00000440246, ENST00000543262
    Conserved Domains (3) summary
    cd05312
    Location:305582
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:114295
    malic; Malic enzyme, N-terminal domain
  3. NM_006680.2NP_006671.2  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_006671.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.
    Source sequence(s)
    AA449933, AI198184, AI948779, AY424278, BC022472, BM906572, X79440
    Consensus CDS
    CCDS8277.1
    UniProtKB/Swiss-Prot
    Q16798
    UniProtKB/TrEMBL
    Q6TCH8
    Conserved Domains (3) summary
    cd05312
    Location:305582
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:114295
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    86441108..86672636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273717.1XP_005273774.1  

    See identical proteins and their annotated locations for XP_005273774.1

    UniProtKB/Swiss-Prot
    Q16798
    Conserved Domains (3) summary
    cd05312
    Location:305582
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:38588
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:114295
    malic; Malic enzyme, N-terminal domain
  2. XM_011544737.1XP_011543039.1  

    Conserved Domains (3) summary
    cd05312
    Location:104381
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:1387
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:194
    malic; Malic enzyme, N-terminal domain
  3. XM_011544735.1XP_011543037.1  

    Related
    ENSP00000315255, ENST00000323418
    Conserved Domains (1) summary
    pfam00390
    Location:114295
    malic; Malic enzyme, N-terminal domain
  4. XM_011544736.1XP_011543038.1  

    Conserved Domains (1) summary
    pfam00390
    Location:114295
    malic; Malic enzyme, N-terminal domain

RNA

  1. XR_949766.1 RNA Sequence

  2. XR_949760.1 RNA Sequence

  3. XR_949762.1 RNA Sequence

  4. XR_949761.1 RNA Sequence

  5. XR_949764.1 RNA Sequence

  6. XR_949765.1 RNA Sequence

  7. XR_949763.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    86037902..86269349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)