Format

Send to:

Choose Destination

ARID5A AT-rich interaction domain 5A [ Homo sapiens (human) ]

Gene ID: 10865, updated on 8-May-2016
Official Symbol
ARID5Aprovided by HGNC
Official Full Name
AT-rich interaction domain 5Aprovided by HGNC
Primary source
HGNC:HGNC:17361
See related
Ensembl:ENSG00000196843 HPRD:12481; MIM:611583; Vega:OTTHUMG00000155229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRF1; MRF-1; RP11-363D14
Summary
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
2q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (96536727..96552634)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97202464..97218375)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene uncharacterized LOC105373496 Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene fer-1 like family member 5 Neighboring gene lectin, mannose binding 2 like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of AT rich interactive domain 5A (ARID5A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
AT-rich interactive domain-containing protein 5A
Names
ARID domain-containing protein 5A
AT rich interactive domain 5A (MRF1-like)
RFVG5814
modulator recognition factor 1
modulator recognition factor I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319085.1NP_001306014.1  AT-rich interactive domain-containing protein 5A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI085152, BC067301, BX396215, HY002073
    Conserved Domains (1) summary
    smart00501
    Location:61202
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  2. NM_001319087.1NP_001306016.1  AT-rich interactive domain-containing protein 5A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AI085152, BC067301, CR981009, HY002073
    Conserved Domains (1) summary
    smart00501
    Location:61201
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  3. NM_001319092.1NP_001306021.1  AT-rich interactive domain-containing protein 5A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC013270, AI085152, BC047390
    UniProtKB/TrEMBL
    C9J1Q0
    Conserved Domains (1) summary
    smart00501
    Location:180
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  4. NM_001319093.1NP_001306022.1  AT-rich interactive domain-containing protein 5A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two alternate splice junctions and lacks an alternate exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5, 6, and 7 all encode the same isoform (e).
    Source sequence(s)
    AC013270, AI085152, BC067301, HY002073, HY076710
  5. NM_001319094.1NP_001306023.1  AT-rich interactive domain-containing protein 5A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two alternate splice junctions compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5, 6, and 7 all encode the same isoform (e).
    Source sequence(s)
    AI085152, BC067301, BM556343, HY002073
  6. NM_001319096.1NP_001306025.1  AT-rich interactive domain-containing protein 5A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses lacks an alternate exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5, 6, and 7 all encode the same isoform (e).
    Source sequence(s)
    AI085152, BX648918, HY002073
  7. NM_212481.2NP_997646.1  AT-rich interactive domain-containing protein 5A isoform c

    See identical proteins and their annotated locations for NP_997646.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI085152, HY002073, M62324
    Consensus CDS
    CCDS33251.1
    UniProtKB/Swiss-Prot
    Q03989
    Related
    ENSP00000350078, OTTHUMP00000207481, ENST00000357485, OTTHUMT00000338888
    Conserved Domains (1) summary
    smart00501
    Location:61148
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    96536727..96552634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263856.1XP_005263913.1  

    Conserved Domains (1) summary
    smart00501
    Location:61201
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  2. XM_005263860.1XP_005263917.1  

  3. XM_011510501.1XP_011508803.1  

    Related
    ENSP00000400785, OTTHUMP00000207483, ENST00000454558, OTTHUMT00000338891
    Conserved Domains (1) summary
    smart00501
    Location:180
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  4. XM_011510500.1XP_011508802.1  

    See identical proteins and their annotated locations for XP_011508802.1

    Conserved Domains (1) summary
    smart00501
    Location:71158
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  5. XM_011510499.1XP_011508801.1  

    See identical proteins and their annotated locations for XP_011508801.1

    Conserved Domains (1) summary
    smart00501
    Location:71158
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    97207299..97223202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006673.2: Suppressed sequence

    Description
    NM_006673.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.