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RUVBL2 RuvB-like AAA ATPase 2 [ Homo sapiens (human) ]

Gene ID: 10856, updated on 11-Aug-2014
Official Symbol
RUVBL2provided by HGNC
Official Full Name
RuvB-like AAA ATPase 2provided by HGNC
Primary source
HGNC:10475
Locus tag
CGI-46
See related
Ensembl:ENSG00000183207; HPRD:16070; MIM:604788; Vega:OTTHUMG00000183333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RVB2; TIH2; ECP51; TIP48; CGI-46; INO80J; REPTIN; TIP49B
Summary
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]
See RUVBL2 in Epigenomics, MapViewer
Location:
19q13.3
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (48993481..49015926)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49496738..49519183)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ferritin, light polypeptide Neighboring gene glycogen synthase 1 (muscle) Neighboring gene microRNA 6798 Neighboring gene uncharacterized LOC101059948 Neighboring gene luteinizing hormone beta polypeptide

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat The core of the p400/TRRAP complex, consists of BAF53A, P400, RUVBL1, RUVBL2, TRRAP, are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent 5'-3' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ATP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
DNA duplex unwinding IDA
Inferred from Direct Assay
more info
PubMed 
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA duplex unwinding TAS
Traceable Author Statement
more info
PubMed 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to estradiol stimulus IMP
Inferred from Mutant Phenotype
more info
 
chromatin organization TAS
Traceable Author Statement
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 
establishment of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 
histone H2A acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of estrogen receptor binding IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
protein folding TAS
Traceable Author Statement
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcriptional activation by promoter-enhancer looping IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
Swr1 complex IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ruvB-like 2
Names
ruvB-like 2
ECP-51
TAP54-beta
reptin52 protein
repressing pontin 52
INO80 complex subunit J
RuvB (E coli homolog)-like 2
48 kDa TBP-interacting protein
TIP60-associated protein 54-beta
51 kDa erythrocyte cytosolic protein
erythrocyte cytosolic protein, 51-KD
48 kDa TATA box-binding protein-interacting protein
NP_006657.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033041.1 

    Range
    5001..27027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006666.1NP_006657.1  ruvB-like 2

    See proteins identical to NP_006657.1

    Status: REVIEWED

    Source sequence(s)
    AB024301
    Consensus CDS
    CCDS42588.1
    UniProtKB/Swiss-Prot
    Q9Y230
    Conserved Domains (3) summary
    cd00009
    Location:269362
    Blast Score: 86
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1224
    Location:15451
    Blast Score: 1687
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]
    cl18944
    Location:73123
    Blast Score: 94
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    48993481..49015926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258426.1XP_005258483.1  

    See proteins identical to XP_005258483.1

    UniProtKB/TrEMBL
    B3KNL2
    Conserved Domains (3) summary
    cd00009
    Location:235328
    Blast Score: 87
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1224
    Location:9417
    Blast Score: 1598
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]
    cl18944
    Location:3989
    Blast Score: 95
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
  2. XM_005258428.1XP_005258485.1  

    See proteins identical to XP_005258485.1

    UniProtKB/TrEMBL
    B3KQ59
    Related
    ENSP00000473172, OTTHUMP00000271478, ENST00000595090, OTTHUMT00000466235
    Conserved Domains (3) summary
    cd00009
    Location:224317
    Blast Score: 86
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1224
    Location:1406
    Blast Score: 1578
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]
    cl18944
    Location:2878
    Blast Score: 94
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
  3. XM_005258427.1XP_005258484.1  

    See proteins identical to XP_005258484.1

    UniProtKB/TrEMBL
    B3KNL2
    Conserved Domains (3) summary
    cd00009
    Location:235328
    Blast Score: 87
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1224
    Location:9417
    Blast Score: 1598
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]
    cl18944
    Location:3989
    Blast Score: 95
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    45873862..45895902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    49499385..49521406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)