U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KMT2A lysine methyltransferase 2A [ Manis javanica (Malayan pangolin) ]

Gene ID: 108384991, updated on 14-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
KMT2A
Gene description
lysine methyltransferase 2A
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: Un
Exon count:
37
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023436136.1 (4293061..4362176, complement)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016528366.1 (279370..346943)

NW_023436136.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene 40S ribosomal protein S15a-like Neighboring gene U2 spliceosomal RNA Neighboring gene putative uncharacterized protein MGC13053 Neighboring gene ATP synthase membrane subunit g

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone methyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
histone-lysine N-methyltransferase 2A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023436136.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    4293061..4362176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036992735.1 → XP_036848630.1  histone-lysine N-methyltransferase 2A isoform X1

    Conserved Domains (11) summary
    cd05493
    Location:1685 → 1815
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    PTZ00449
    Location:1275 → 1387
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00542
    Location:3696 → 3778
    FYRC; FY-rich domain, C-terminal region
    cd15588
    Location:1468 → 1514
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:1516 → 1565
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:1603 → 1662
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:1909 → 2021
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05109
    Location:3170 → 3400
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02008
    Location:1182 → 1229
    zf-CXXC; CXXC zinc finger domain
    cd19170
    Location:3843 → 3996
    SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    pfam05964
    Location:2062 → 2109
    FYRN; F/Y-rich N-terminus

  2. XM_036992736.1 → XP_036848631.1  histone-lysine N-methyltransferase 2A isoform X2

    Conserved Domains (11) summary
    cd05493
    Location:1652 → 1782
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    PTZ00449
    Location:1242 → 1354
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00542
    Location:3663 → 3745
    FYRC; FY-rich domain, C-terminal region
    cd15588
    Location:1435 → 1481
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:1483 → 1532
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:1570 → 1629
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:1876 → 1988
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05109
    Location:3137 → 3367
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02008
    Location:1149 → 1196
    zf-CXXC; CXXC zinc finger domain
    cd19170
    Location:3810 → 3963
    SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    pfam05964
    Location:2029 → 2076
    FYRN; F/Y-rich N-terminus

  3. XM_017642251.2 → XP_017497740.2  histone-lysine N-methyltransferase 2A isoform X3

    Conserved Domains (11) summary
    cd05493
    Location:1649 → 1779
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    PTZ00449
    Location:1242 → 1354
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00542
    Location:3660 → 3742
    FYRC; FY-rich domain, C-terminal region
    cd15588
    Location:1435 → 1481
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:1483 → 1532
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:1570 → 1626
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:1873 → 1985
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05109
    Location:3134 → 3364
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02008
    Location:1149 → 1196
    zf-CXXC; CXXC zinc finger domain
    cd19170
    Location:3807 → 3960
    SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    pfam05964
    Location:2026 → 2073
    FYRN; F/Y-rich N-terminus
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.